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Imatinib-induced decompensated heart failure in an elderly patient with chronic myeloid leukemia: case report and literature review

Because it is safe and well tolerated, imatinib is a standard first-line therapy for chronic myeloid leukemia (CML). Although there have been sporadic reports of imatinib-induced cardiotoxicity, including left ventricle (LV) dysfunction and heart failure, the evidence for it is contradictory. Here,...

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Autores principales: Ran, Hai-Hong, Zhang, Ran, Lu, Xue-Chun, Yang, Bo, Fan, Hui, Zhu, Hong-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545260/
https://www.ncbi.nlm.nih.gov/pubmed/23341847
http://dx.doi.org/10.3724/SP.J.1263.2012.05251
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author Ran, Hai-Hong
Zhang, Ran
Lu, Xue-Chun
Yang, Bo
Fan, Hui
Zhu, Hong-Li
author_facet Ran, Hai-Hong
Zhang, Ran
Lu, Xue-Chun
Yang, Bo
Fan, Hui
Zhu, Hong-Li
author_sort Ran, Hai-Hong
collection PubMed
description Because it is safe and well tolerated, imatinib is a standard first-line therapy for chronic myeloid leukemia (CML). Although there have been sporadic reports of imatinib-induced cardiotoxicity, including left ventricle (LV) dysfunction and heart failure, the evidence for it is contradictory. Here, we reported a case of an 88-year-old male patient with CML developed decompensated heart failure following imatinib therapy. Four days after the initiation of imatinib, the patient developed orthopnea, edema and a pleural effusion accompanied by abdominal distension, nausea and vomiting. The chest X-ray film showed an enlarged cardiac profile. The echocardiogram demonstrated a decreased LV ejection fraction and enlarged left-side cardiac chambers. B-type natriuretic peptide concentrations were markedly increased. The patient recovered soon after the withdrawal of imatinib and introduction of comprehensive therapy for heart failure. Imatinib-induced cardiotoxicity in elderly patients is a potentially serious complication that merits further evaluation.
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spelling pubmed-35452602013-01-22 Imatinib-induced decompensated heart failure in an elderly patient with chronic myeloid leukemia: case report and literature review Ran, Hai-Hong Zhang, Ran Lu, Xue-Chun Yang, Bo Fan, Hui Zhu, Hong-Li J Geriatr Cardiol Case Report Because it is safe and well tolerated, imatinib is a standard first-line therapy for chronic myeloid leukemia (CML). Although there have been sporadic reports of imatinib-induced cardiotoxicity, including left ventricle (LV) dysfunction and heart failure, the evidence for it is contradictory. Here, we reported a case of an 88-year-old male patient with CML developed decompensated heart failure following imatinib therapy. Four days after the initiation of imatinib, the patient developed orthopnea, edema and a pleural effusion accompanied by abdominal distension, nausea and vomiting. The chest X-ray film showed an enlarged cardiac profile. The echocardiogram demonstrated a decreased LV ejection fraction and enlarged left-side cardiac chambers. B-type natriuretic peptide concentrations were markedly increased. The patient recovered soon after the withdrawal of imatinib and introduction of comprehensive therapy for heart failure. Imatinib-induced cardiotoxicity in elderly patients is a potentially serious complication that merits further evaluation. Science Press 2012-12 /pmc/articles/PMC3545260/ /pubmed/23341847 http://dx.doi.org/10.3724/SP.J.1263.2012.05251 Text en Institute of Geriatric Cardiology http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Case Report
Ran, Hai-Hong
Zhang, Ran
Lu, Xue-Chun
Yang, Bo
Fan, Hui
Zhu, Hong-Li
Imatinib-induced decompensated heart failure in an elderly patient with chronic myeloid leukemia: case report and literature review
title Imatinib-induced decompensated heart failure in an elderly patient with chronic myeloid leukemia: case report and literature review
title_full Imatinib-induced decompensated heart failure in an elderly patient with chronic myeloid leukemia: case report and literature review
title_fullStr Imatinib-induced decompensated heart failure in an elderly patient with chronic myeloid leukemia: case report and literature review
title_full_unstemmed Imatinib-induced decompensated heart failure in an elderly patient with chronic myeloid leukemia: case report and literature review
title_short Imatinib-induced decompensated heart failure in an elderly patient with chronic myeloid leukemia: case report and literature review
title_sort imatinib-induced decompensated heart failure in an elderly patient with chronic myeloid leukemia: case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545260/
https://www.ncbi.nlm.nih.gov/pubmed/23341847
http://dx.doi.org/10.3724/SP.J.1263.2012.05251
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