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A systems approach defining constraints of the genome architecture on lineage selection and evolvability during somatic cancer evolution

Most clinically distinguishable malignant tumors are characterized by specific mutations, specific patterns of chromosomal rearrangements and a predominant mechanism of genetic instability but it remains unsolved whether modifications of cancer genomes can be explained solely by mutations and select...

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Detalles Bibliográficos
Autores principales: Rübben, Albert, Nordhoff, Ole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545268/
https://www.ncbi.nlm.nih.gov/pubmed/23336076
http://dx.doi.org/10.1242/bio.20122543

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