Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation

The human germinal centre associated lymphoma (HGAL) gene is specifically expressed in germinal centre B-lymphocytes and germinal centre-derived B-cell lymphomas, but its function is largely unknown. Here we demonstrate that HGAL directly binds Syk in B-cells, increases its kinase activity upon B-ce...

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Detalles Bibliográficos
Autores principales: Romero-Camarero, Isabel, Jiang, Xiaoyu, Natkunam, Yasodha, Lu, Xiaoqing, Vicente-Dueñas, Carolina, Gonzalez-Herrero, Ines, Flores, Teresa, Garcia, Juan Luis, McNamara, George, Kunder, Christian, Zhao, Shuchun, Segura, Victor, Fontan, Lorena, Martínez-Climent, Jose A., García-Criado, Francisco Javier, Theis, Jason D., Dogan, Ahmet, Campos-Sánchez, Elena, Green, Michael R., Alizadeh, Ash A., Cobaleda, Cesar, Sánchez-García, Isidro, Lossos, Izidore S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545406/
https://www.ncbi.nlm.nih.gov/pubmed/23299888
http://dx.doi.org/10.1038/ncomms2334

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