The fetal fraction of cell-free DNA in maternal plasma is not affected by a priori risk of fetal trisomy

OBJECTIVE: To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood. METHODS: A comparative analysis on fetal cfDNA amounts was performed in subjects stratified into a priori risk groups based on maternal age, prenatal sc...

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Autores principales: Brar, Herb, Wang, Eric, Struble, Craig, Musci, Thomas J., Norton, Mary E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2013
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545542/
https://www.ncbi.nlm.nih.gov/pubmed/22913322
http://dx.doi.org/10.3109/14767058.2012.722731
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author Brar, Herb
Wang, Eric
Struble, Craig
Musci, Thomas J.
Norton, Mary E.
author_facet Brar, Herb
Wang, Eric
Struble, Craig
Musci, Thomas J.
Norton, Mary E.
author_sort Brar, Herb
collection PubMed
description OBJECTIVE: To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood. METHODS: A comparative analysis on fetal cfDNA amounts was performed in subjects stratified into a priori risk groups based on maternal age, prenatal screening results, or nuchal translucency measurement. RESULTS: Across the highest and lowest deciles within each group, there were no significant differences in the fetal cfDNA fraction. CONCLUSIONS: These data support the concept that non-invasive prenatal test performance as determined by fetal cfDNA fraction is not predicted to be different based on patient risk classification.
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spelling pubmed-35455422013-01-16 The fetal fraction of cell-free DNA in maternal plasma is not affected by a priori risk of fetal trisomy Brar, Herb Wang, Eric Struble, Craig Musci, Thomas J. Norton, Mary E. J Matern Fetal Neonatal Med Short Reports OBJECTIVE: To determine the relationship between a priori risk for fetal trisomy and the fraction of fetal cell-free DNA (cfDNA) in maternal blood. METHODS: A comparative analysis on fetal cfDNA amounts was performed in subjects stratified into a priori risk groups based on maternal age, prenatal screening results, or nuchal translucency measurement. RESULTS: Across the highest and lowest deciles within each group, there were no significant differences in the fetal cfDNA fraction. CONCLUSIONS: These data support the concept that non-invasive prenatal test performance as determined by fetal cfDNA fraction is not predicted to be different based on patient risk classification. Informa Healthcare 2013-01 2012-09-12 /pmc/articles/PMC3545542/ /pubmed/22913322 http://dx.doi.org/10.3109/14767058.2012.722731 Text en © 2013 Informa UK, Ltd. http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited.
spellingShingle Short Reports
Brar, Herb
Wang, Eric
Struble, Craig
Musci, Thomas J.
Norton, Mary E.
The fetal fraction of cell-free DNA in maternal plasma is not affected by a priori risk of fetal trisomy
title The fetal fraction of cell-free DNA in maternal plasma is not affected by a priori risk of fetal trisomy
title_full The fetal fraction of cell-free DNA in maternal plasma is not affected by a priori risk of fetal trisomy
title_fullStr The fetal fraction of cell-free DNA in maternal plasma is not affected by a priori risk of fetal trisomy
title_full_unstemmed The fetal fraction of cell-free DNA in maternal plasma is not affected by a priori risk of fetal trisomy
title_short The fetal fraction of cell-free DNA in maternal plasma is not affected by a priori risk of fetal trisomy
title_sort fetal fraction of cell-free dna in maternal plasma is not affected by a priori risk of fetal trisomy
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545542/
https://www.ncbi.nlm.nih.gov/pubmed/22913322
http://dx.doi.org/10.3109/14767058.2012.722731
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