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Galanin-expression and galanin-dependent sensory neurons are not required for itch
BACKGROUND: Galanin is a key modulator of nociception, and it is also required for the developmental survival of a subset of C-fibre sensory neurons which are critical to the mediation of neuropathic and inflammatory pain. However, the potential modulatory roles played by galanin, or the galanin-dep...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545919/ https://www.ncbi.nlm.nih.gov/pubmed/23216829 http://dx.doi.org/10.1186/1744-8069-8-87 |
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author | Holmes, Fiona E Vanderplank, Penny Wynick, David |
author_facet | Holmes, Fiona E Vanderplank, Penny Wynick, David |
author_sort | Holmes, Fiona E |
collection | PubMed |
description | BACKGROUND: Galanin is a key modulator of nociception, and it is also required for the developmental survival of a subset of C-fibre sensory neurons which are critical to the mediation of neuropathic and inflammatory pain. However, the potential modulatory roles played by galanin, or the galanin-dependent neurons, in pruritoceptive mechanisms underlying the sensation of itch have not been investigated. FINDINGS: Here we report that mice carrying a loss-of-function mutation in the galanin gene (Gal-KO) show no differences in spontaneous behavioural itch responses compared to wild-type (WT) controls. Similarly, the responses to a range of pruritogens are not significantly different between the two genotypes. CONCLUSIONS: These results suggest that neither galanin expression, nor the galanin-dependent subpopulation of sensory neurons is required for itch-related behaviours. |
format | Online Article Text |
id | pubmed-3545919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35459192013-01-17 Galanin-expression and galanin-dependent sensory neurons are not required for itch Holmes, Fiona E Vanderplank, Penny Wynick, David Mol Pain Short Report BACKGROUND: Galanin is a key modulator of nociception, and it is also required for the developmental survival of a subset of C-fibre sensory neurons which are critical to the mediation of neuropathic and inflammatory pain. However, the potential modulatory roles played by galanin, or the galanin-dependent neurons, in pruritoceptive mechanisms underlying the sensation of itch have not been investigated. FINDINGS: Here we report that mice carrying a loss-of-function mutation in the galanin gene (Gal-KO) show no differences in spontaneous behavioural itch responses compared to wild-type (WT) controls. Similarly, the responses to a range of pruritogens are not significantly different between the two genotypes. CONCLUSIONS: These results suggest that neither galanin expression, nor the galanin-dependent subpopulation of sensory neurons is required for itch-related behaviours. BioMed Central 2012-12-05 /pmc/articles/PMC3545919/ /pubmed/23216829 http://dx.doi.org/10.1186/1744-8069-8-87 Text en Copyright ©2012 Holmes et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Holmes, Fiona E Vanderplank, Penny Wynick, David Galanin-expression and galanin-dependent sensory neurons are not required for itch |
title | Galanin-expression and galanin-dependent sensory neurons are not required for itch |
title_full | Galanin-expression and galanin-dependent sensory neurons are not required for itch |
title_fullStr | Galanin-expression and galanin-dependent sensory neurons are not required for itch |
title_full_unstemmed | Galanin-expression and galanin-dependent sensory neurons are not required for itch |
title_short | Galanin-expression and galanin-dependent sensory neurons are not required for itch |
title_sort | galanin-expression and galanin-dependent sensory neurons are not required for itch |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545919/ https://www.ncbi.nlm.nih.gov/pubmed/23216829 http://dx.doi.org/10.1186/1744-8069-8-87 |
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