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Specific Disruption of Tsc1 in Ovarian Granulosa Cells Promotes Ovulation and Causes Progressive Accumulation of Corpora Lutea

Tuberous sclerosis complex 1 (Tsc1) is a tumor suppressor negatively regulating mammalian target of rapamycin complex 1 (mTORC1). It is reported that mice lacking Tsc1 gene in oocytes show depletion of primordial follicles, resulting in premature ovarian failure and subsequent infertility. A recent...

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Detalles Bibliográficos
Autores principales:	Huang, Lin, Wang, Zhen-Bo, Jiang, Zong-Zhe, Hu, Meng-Wen, Lin, Fei, Zhang, Qing-Hua, Luo, Yi-Bo, Hou, Yi, Zhao, Yong, Fan, Heng-Yu, Schatten, Heide, Sun, Qing-Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545997/ https://www.ncbi.nlm.nih.gov/pubmed/23335988 http://dx.doi.org/10.1371/journal.pone.0054052

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