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Poly(I:C)/Alum Mixed Adjuvant Priming Enhances HBV Subunit Vaccine-Induced Immunity in Mice When Combined with Recombinant Adenoviral-Based HBV Vaccine Boosting
BACKGROUND: Virus-specific cellular immune responses play a critical role in virus clearance during acute or chronic HBV infection. Currently, the commercially available HBV vaccine is combined with alum adjuvant, which stimulates mainly Th2 immune responses. Therefore, development of new therapeuti...
Autores principales: | Chuai, Xia, Chen, Hong, Wang, Wen, Deng, Yao, Wen, Bo, Ruan, Li, Tan, Wenjie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545998/ https://www.ncbi.nlm.nih.gov/pubmed/23335993 http://dx.doi.org/10.1371/journal.pone.0054126 |
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