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Circadian Timekeeping Is Disturbed in Rheumatoid Arthritis at Molecular Level

INTRODUCTION: Patients with rheumatoid arthritis (RA) have disturbances in the hypothalamic-pituitary-adrenal (HPA) axis. These are reflected in altered circadian rhythm of circulating serum cortisol, melatonin and IL-6 levels and in chronic fatigue. We hypothesized that the molecular machinery resp...

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Detalles Bibliográficos
Autores principales:	Kouri, Vesa-Petteri, Olkkonen, Juri, Kaivosoja, Emilia, Ainola, Mari, Juhila, Juuso, Hovatta, Iiris, Konttinen, Yrjö T., Mandelin, Jami
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546002/ https://www.ncbi.nlm.nih.gov/pubmed/23335987 http://dx.doi.org/10.1371/journal.pone.0054049

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