DNA Sequence Variants in PPARGC1A, a Gene Encoding a Coactivator of the ω-3 LCPUFA Sensing PPAR-RXR Transcription Complex, Are Associated with NV AMD and AMD-Associated Loci in Genes of Complement and VEGF Signaling Pathways

BACKGROUND: Increased intake of ω-3 long-chain polyunsaturated fatty acids (LCPUFAs) and use of peroxisome proliferator activator receptor (PPAR)-activating drugs are associated with attenuation of pathologic retinal angiogenesis. ω-3 LCPUFAs are endogenous agonists of PPARs. We postulated that DNA...

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Detalles Bibliográficos
Autores principales: SanGiovanni, John Paul, Chen, Jing, Sapieha, Przemyslaw, Aderman, Christopher M., Stahl, Andreas, Clemons, Traci E., Chew, Emily Y., Smith, Lois E. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546058/
https://www.ncbi.nlm.nih.gov/pubmed/23335958
http://dx.doi.org/10.1371/journal.pone.0053155

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