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Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilisation: cross sectional study
Objective To estimate the risk of pulmonary embolism and venous thromboembolism in pregnant women after in vitro fertilisation. Design Cross sectional study. Setting Sweden. Participants 23 498 women who had given birth after in vitro fertilisation between 1990 and 2008 and 116 960 individually matc...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group Ltd.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546085/ https://www.ncbi.nlm.nih.gov/pubmed/23321489 http://dx.doi.org/10.1136/bmj.e8632 |
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author | Henriksson, Peter Westerlund, Eli Wallén, Håkan Brandt, Lena Hovatta, Outi Ekbom, Anders |
author_facet | Henriksson, Peter Westerlund, Eli Wallén, Håkan Brandt, Lena Hovatta, Outi Ekbom, Anders |
author_sort | Henriksson, Peter |
collection | PubMed |
description | Objective To estimate the risk of pulmonary embolism and venous thromboembolism in pregnant women after in vitro fertilisation. Design Cross sectional study. Setting Sweden. Participants 23 498 women who had given birth after in vitro fertilisation between 1990 and 2008 and 116 960 individually matched women with natural pregnancies. Main outcome measures Risk of pulmonary embolism and venous thromboembolism (identified by linkage to the Swedish national patient register) during the whole pregnancy and by trimester. Results Venous thromboembolism occurred in 4.2/1000 women (n=99) after in vitro fertilisation compared with 2.5/1000 (n=291) in women with natural pregnancies (hazard ratio 1.77, 95% confidence interval 1.41 to 2.23). The risk of venous thromboembolism was increased during the whole pregnancy (P<0.001) and differed between the trimesters (P=0.002). The risk was particularly increased during the first trimester, at 1.5/1000 after in vitro fertilisation versus 0.3/1000 (hazard ratio 4.22, 2.46 to 7.26). The proportion of women experiencing pulmonary embolism during the first trimester was 3.0/10 000 after in vitro fertilisation versus 0.4/10 000 (hazard ratio 6.97, 2.21 to 21.96). Conclusions In vitro fertilisation is associated with an increased risk of pulmonary embolism and venous thromboembolism during the first trimester. The risk of pulmonary embolism is low in absolute terms but because the condition is a leading cause of maternal mortality and clinical suspicion is critical for diagnosis, an awareness of this risk is important. Trial registration ClinicalTrials.gov NCT01524393. |
format | Online Article Text |
id | pubmed-3546085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BMJ Publishing Group Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-35460852013-01-16 Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilisation: cross sectional study Henriksson, Peter Westerlund, Eli Wallén, Håkan Brandt, Lena Hovatta, Outi Ekbom, Anders BMJ Research Objective To estimate the risk of pulmonary embolism and venous thromboembolism in pregnant women after in vitro fertilisation. Design Cross sectional study. Setting Sweden. Participants 23 498 women who had given birth after in vitro fertilisation between 1990 and 2008 and 116 960 individually matched women with natural pregnancies. Main outcome measures Risk of pulmonary embolism and venous thromboembolism (identified by linkage to the Swedish national patient register) during the whole pregnancy and by trimester. Results Venous thromboembolism occurred in 4.2/1000 women (n=99) after in vitro fertilisation compared with 2.5/1000 (n=291) in women with natural pregnancies (hazard ratio 1.77, 95% confidence interval 1.41 to 2.23). The risk of venous thromboembolism was increased during the whole pregnancy (P<0.001) and differed between the trimesters (P=0.002). The risk was particularly increased during the first trimester, at 1.5/1000 after in vitro fertilisation versus 0.3/1000 (hazard ratio 4.22, 2.46 to 7.26). The proportion of women experiencing pulmonary embolism during the first trimester was 3.0/10 000 after in vitro fertilisation versus 0.4/10 000 (hazard ratio 6.97, 2.21 to 21.96). Conclusions In vitro fertilisation is associated with an increased risk of pulmonary embolism and venous thromboembolism during the first trimester. The risk of pulmonary embolism is low in absolute terms but because the condition is a leading cause of maternal mortality and clinical suspicion is critical for diagnosis, an awareness of this risk is important. Trial registration ClinicalTrials.gov NCT01524393. BMJ Publishing Group Ltd. 2013-01-15 /pmc/articles/PMC3546085/ /pubmed/23321489 http://dx.doi.org/10.1136/bmj.e8632 Text en © Henriksson et al 2013 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode. |
spellingShingle | Research Henriksson, Peter Westerlund, Eli Wallén, Håkan Brandt, Lena Hovatta, Outi Ekbom, Anders Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilisation: cross sectional study |
title | Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilisation: cross sectional study |
title_full | Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilisation: cross sectional study |
title_fullStr | Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilisation: cross sectional study |
title_full_unstemmed | Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilisation: cross sectional study |
title_short | Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilisation: cross sectional study |
title_sort | incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilisation: cross sectional study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546085/ https://www.ncbi.nlm.nih.gov/pubmed/23321489 http://dx.doi.org/10.1136/bmj.e8632 |
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