Cargando…
Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy
PURPOSE: For recurrent esophageal cancer after primary definitive radiotherapy, no general treatment guidelines are available. We evaluated the toxicities and clinical outcomes of re-irradiation (re-RT) for recurrent esophageal cancer. MATERIALS AND METHODS: We analyzed 10 patients with recurrent es...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society for Radiation Oncology
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546286/ https://www.ncbi.nlm.nih.gov/pubmed/23346537 http://dx.doi.org/10.3857/roj.2012.30.4.182 |
_version_ | 1782256027880652800 |
---|---|
author | Kim, Young Suk Lee, Chang Geol Kim, Kyung Hwan Kim, Taehyung Lee, Joohwan Cho, Yona Koom, Woong Sub |
author_facet | Kim, Young Suk Lee, Chang Geol Kim, Kyung Hwan Kim, Taehyung Lee, Joohwan Cho, Yona Koom, Woong Sub |
author_sort | Kim, Young Suk |
collection | PubMed |
description | PURPOSE: For recurrent esophageal cancer after primary definitive radiotherapy, no general treatment guidelines are available. We evaluated the toxicities and clinical outcomes of re-irradiation (re-RT) for recurrent esophageal cancer. MATERIALS AND METHODS: We analyzed 10 patients with recurrent esophageal cancer treated with re-RT after primary definitive radiotherapy. The median time interval between primary radiotherapy and re-RT was 15.6 months (range, 4.8 to 36.4 months). The total dose of primary radiotherapy was a median of 50.4 Gy (range, 50.4 to 63.0 Gy). The total dose of re-RT was a median of 46.5 Gy (range, 44.0 to 50.4 Gy). RESULTS: The median follow-up period was 4.9 months (range, 2.6 to 11.4 months). The tumor response at 3 months after the end of re-RT was complete response (n = 2), partial response (n = 1), stable disease (n = 2), and progressive disease (n = 5). Grade 5 tracheoesophageal fistula developed in three patients. The time interval between primary radiotherapy and re-RT was less than 12 months in two of these three patients. Late toxicities included grade 1 dysphagia (n = 1). CONCLUSION: Re-RT of recurrent esophageal cancer after primary radiotherapy can cause severe toxicity. |
format | Online Article Text |
id | pubmed-3546286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Korean Society for Radiation Oncology |
record_format | MEDLINE/PubMed |
spelling | pubmed-35462862013-01-23 Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy Kim, Young Suk Lee, Chang Geol Kim, Kyung Hwan Kim, Taehyung Lee, Joohwan Cho, Yona Koom, Woong Sub Radiat Oncol J Original Article PURPOSE: For recurrent esophageal cancer after primary definitive radiotherapy, no general treatment guidelines are available. We evaluated the toxicities and clinical outcomes of re-irradiation (re-RT) for recurrent esophageal cancer. MATERIALS AND METHODS: We analyzed 10 patients with recurrent esophageal cancer treated with re-RT after primary definitive radiotherapy. The median time interval between primary radiotherapy and re-RT was 15.6 months (range, 4.8 to 36.4 months). The total dose of primary radiotherapy was a median of 50.4 Gy (range, 50.4 to 63.0 Gy). The total dose of re-RT was a median of 46.5 Gy (range, 44.0 to 50.4 Gy). RESULTS: The median follow-up period was 4.9 months (range, 2.6 to 11.4 months). The tumor response at 3 months after the end of re-RT was complete response (n = 2), partial response (n = 1), stable disease (n = 2), and progressive disease (n = 5). Grade 5 tracheoesophageal fistula developed in three patients. The time interval between primary radiotherapy and re-RT was less than 12 months in two of these three patients. Late toxicities included grade 1 dysphagia (n = 1). CONCLUSION: Re-RT of recurrent esophageal cancer after primary radiotherapy can cause severe toxicity. The Korean Society for Radiation Oncology 2012-12 2012-12-31 /pmc/articles/PMC3546286/ /pubmed/23346537 http://dx.doi.org/10.3857/roj.2012.30.4.182 Text en Copyright © 2012. The Korean Society for Radiation Oncology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Young Suk Lee, Chang Geol Kim, Kyung Hwan Kim, Taehyung Lee, Joohwan Cho, Yona Koom, Woong Sub Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy |
title | Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy |
title_full | Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy |
title_fullStr | Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy |
title_full_unstemmed | Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy |
title_short | Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy |
title_sort | re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546286/ https://www.ncbi.nlm.nih.gov/pubmed/23346537 http://dx.doi.org/10.3857/roj.2012.30.4.182 |
work_keys_str_mv | AT kimyoungsuk reirradiationofrecurrentesophagealcancerafterprimarydefinitiveradiotherapy AT leechanggeol reirradiationofrecurrentesophagealcancerafterprimarydefinitiveradiotherapy AT kimkyunghwan reirradiationofrecurrentesophagealcancerafterprimarydefinitiveradiotherapy AT kimtaehyung reirradiationofrecurrentesophagealcancerafterprimarydefinitiveradiotherapy AT leejoohwan reirradiationofrecurrentesophagealcancerafterprimarydefinitiveradiotherapy AT choyona reirradiationofrecurrentesophagealcancerafterprimarydefinitiveradiotherapy AT koomwoongsub reirradiationofrecurrentesophagealcancerafterprimarydefinitiveradiotherapy |