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Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy

PURPOSE: For recurrent esophageal cancer after primary definitive radiotherapy, no general treatment guidelines are available. We evaluated the toxicities and clinical outcomes of re-irradiation (re-RT) for recurrent esophageal cancer. MATERIALS AND METHODS: We analyzed 10 patients with recurrent es...

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Autores principales: Kim, Young Suk, Lee, Chang Geol, Kim, Kyung Hwan, Kim, Taehyung, Lee, Joohwan, Cho, Yona, Koom, Woong Sub
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Radiation Oncology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546286/
https://www.ncbi.nlm.nih.gov/pubmed/23346537
http://dx.doi.org/10.3857/roj.2012.30.4.182
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author Kim, Young Suk
Lee, Chang Geol
Kim, Kyung Hwan
Kim, Taehyung
Lee, Joohwan
Cho, Yona
Koom, Woong Sub
author_facet Kim, Young Suk
Lee, Chang Geol
Kim, Kyung Hwan
Kim, Taehyung
Lee, Joohwan
Cho, Yona
Koom, Woong Sub
author_sort Kim, Young Suk
collection PubMed
description PURPOSE: For recurrent esophageal cancer after primary definitive radiotherapy, no general treatment guidelines are available. We evaluated the toxicities and clinical outcomes of re-irradiation (re-RT) for recurrent esophageal cancer. MATERIALS AND METHODS: We analyzed 10 patients with recurrent esophageal cancer treated with re-RT after primary definitive radiotherapy. The median time interval between primary radiotherapy and re-RT was 15.6 months (range, 4.8 to 36.4 months). The total dose of primary radiotherapy was a median of 50.4 Gy (range, 50.4 to 63.0 Gy). The total dose of re-RT was a median of 46.5 Gy (range, 44.0 to 50.4 Gy). RESULTS: The median follow-up period was 4.9 months (range, 2.6 to 11.4 months). The tumor response at 3 months after the end of re-RT was complete response (n = 2), partial response (n = 1), stable disease (n = 2), and progressive disease (n = 5). Grade 5 tracheoesophageal fistula developed in three patients. The time interval between primary radiotherapy and re-RT was less than 12 months in two of these three patients. Late toxicities included grade 1 dysphagia (n = 1). CONCLUSION: Re-RT of recurrent esophageal cancer after primary radiotherapy can cause severe toxicity.
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spelling pubmed-35462862013-01-23 Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy Kim, Young Suk Lee, Chang Geol Kim, Kyung Hwan Kim, Taehyung Lee, Joohwan Cho, Yona Koom, Woong Sub Radiat Oncol J Original Article PURPOSE: For recurrent esophageal cancer after primary definitive radiotherapy, no general treatment guidelines are available. We evaluated the toxicities and clinical outcomes of re-irradiation (re-RT) for recurrent esophageal cancer. MATERIALS AND METHODS: We analyzed 10 patients with recurrent esophageal cancer treated with re-RT after primary definitive radiotherapy. The median time interval between primary radiotherapy and re-RT was 15.6 months (range, 4.8 to 36.4 months). The total dose of primary radiotherapy was a median of 50.4 Gy (range, 50.4 to 63.0 Gy). The total dose of re-RT was a median of 46.5 Gy (range, 44.0 to 50.4 Gy). RESULTS: The median follow-up period was 4.9 months (range, 2.6 to 11.4 months). The tumor response at 3 months after the end of re-RT was complete response (n = 2), partial response (n = 1), stable disease (n = 2), and progressive disease (n = 5). Grade 5 tracheoesophageal fistula developed in three patients. The time interval between primary radiotherapy and re-RT was less than 12 months in two of these three patients. Late toxicities included grade 1 dysphagia (n = 1). CONCLUSION: Re-RT of recurrent esophageal cancer after primary radiotherapy can cause severe toxicity. The Korean Society for Radiation Oncology 2012-12 2012-12-31 /pmc/articles/PMC3546286/ /pubmed/23346537 http://dx.doi.org/10.3857/roj.2012.30.4.182 Text en Copyright © 2012. The Korean Society for Radiation Oncology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Young Suk
Lee, Chang Geol
Kim, Kyung Hwan
Kim, Taehyung
Lee, Joohwan
Cho, Yona
Koom, Woong Sub
Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy
title Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy
title_full Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy
title_fullStr Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy
title_full_unstemmed Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy
title_short Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy
title_sort re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546286/
https://www.ncbi.nlm.nih.gov/pubmed/23346537
http://dx.doi.org/10.3857/roj.2012.30.4.182
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