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The role of postoperative pelvic radiation in stage IV rectal cancer after resection of primary tumor

PURPOSE: To evaluate the effect of pelvic radiotherapy (RT) in patients with stage IV rectal cancer treated with resection of primary tumor with or without metastasectomy. MATERIALS AND METHODS: Medical records of 112 patients with stage IV rectal cancer treated with resection of primary tumor betwe...

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Autores principales: Lee, Joo Hwan, Jo, In Young, Lee, Jong Hoon, Yoon, Sei Chul, Kim, Yeon-Sil, Choi, Byung Ock, Kim, Jun-Gi, Oh, Seong Taek, Lee, Myeong A, Jang, Hong-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Radiation Oncology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546289/
https://www.ncbi.nlm.nih.gov/pubmed/23346540
http://dx.doi.org/10.3857/roj.2012.30.4.205
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author Lee, Joo Hwan
Jo, In Young
Lee, Jong Hoon
Yoon, Sei Chul
Kim, Yeon-Sil
Choi, Byung Ock
Kim, Jun-Gi
Oh, Seong Taek
Lee, Myeong A
Jang, Hong-Seok
author_facet Lee, Joo Hwan
Jo, In Young
Lee, Jong Hoon
Yoon, Sei Chul
Kim, Yeon-Sil
Choi, Byung Ock
Kim, Jun-Gi
Oh, Seong Taek
Lee, Myeong A
Jang, Hong-Seok
author_sort Lee, Joo Hwan
collection PubMed
description PURPOSE: To evaluate the effect of pelvic radiotherapy (RT) in patients with stage IV rectal cancer treated with resection of primary tumor with or without metastasectomy. MATERIALS AND METHODS: Medical records of 112 patients with stage IV rectal cancer treated with resection of primary tumor between 1990 and 2011 were retrospectively reviewed. Fifty-nine patients received synchronous or staged metastasectomy whereas fifty-three patients did not. Twenty-six patients received pelvic radiotherapy. RESULTS: Median overall survival (OS), locoregional recurrence-free survival (LRFS), and progression-free survival (PFS) of all patients was 27, 70, and 11 months, respectively. Pathologic T (pT), N (pN) classification and complete metastasectomy were statistically significant factors in OS (p = 0.040, 0.020, and 0.002, respectively). RT did not improve OS or LRFS. There were no significant factors in LRFS. pT and pN classification were also significant prognostic factors in PFS (p = 0.010 and p = 0.033, respectively). In the subgroup analysis, RT improved LRFS in patients with pT4 disease (p = 0.026). The locoregional failure rate of the RT group and the non-RT group were 23.1% and 33.7%, showing no difference in the failure pattern of both groups (p = 0.260). CONCLUSION: Postoperative pelvic RT did not improve LRFS of all metastatic rectal cancer patients; however, it can be recommended to patients with pT4 disease. A complete resection of metastatic masses should be performed if possible.
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spelling pubmed-35462892013-01-23 The role of postoperative pelvic radiation in stage IV rectal cancer after resection of primary tumor Lee, Joo Hwan Jo, In Young Lee, Jong Hoon Yoon, Sei Chul Kim, Yeon-Sil Choi, Byung Ock Kim, Jun-Gi Oh, Seong Taek Lee, Myeong A Jang, Hong-Seok Radiat Oncol J Original Article PURPOSE: To evaluate the effect of pelvic radiotherapy (RT) in patients with stage IV rectal cancer treated with resection of primary tumor with or without metastasectomy. MATERIALS AND METHODS: Medical records of 112 patients with stage IV rectal cancer treated with resection of primary tumor between 1990 and 2011 were retrospectively reviewed. Fifty-nine patients received synchronous or staged metastasectomy whereas fifty-three patients did not. Twenty-six patients received pelvic radiotherapy. RESULTS: Median overall survival (OS), locoregional recurrence-free survival (LRFS), and progression-free survival (PFS) of all patients was 27, 70, and 11 months, respectively. Pathologic T (pT), N (pN) classification and complete metastasectomy were statistically significant factors in OS (p = 0.040, 0.020, and 0.002, respectively). RT did not improve OS or LRFS. There were no significant factors in LRFS. pT and pN classification were also significant prognostic factors in PFS (p = 0.010 and p = 0.033, respectively). In the subgroup analysis, RT improved LRFS in patients with pT4 disease (p = 0.026). The locoregional failure rate of the RT group and the non-RT group were 23.1% and 33.7%, showing no difference in the failure pattern of both groups (p = 0.260). CONCLUSION: Postoperative pelvic RT did not improve LRFS of all metastatic rectal cancer patients; however, it can be recommended to patients with pT4 disease. A complete resection of metastatic masses should be performed if possible. The Korean Society for Radiation Oncology 2012-12 2012-12-31 /pmc/articles/PMC3546289/ /pubmed/23346540 http://dx.doi.org/10.3857/roj.2012.30.4.205 Text en Copyright © 2012. The Korean Society for Radiation Oncology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Joo Hwan
Jo, In Young
Lee, Jong Hoon
Yoon, Sei Chul
Kim, Yeon-Sil
Choi, Byung Ock
Kim, Jun-Gi
Oh, Seong Taek
Lee, Myeong A
Jang, Hong-Seok
The role of postoperative pelvic radiation in stage IV rectal cancer after resection of primary tumor
title The role of postoperative pelvic radiation in stage IV rectal cancer after resection of primary tumor
title_full The role of postoperative pelvic radiation in stage IV rectal cancer after resection of primary tumor
title_fullStr The role of postoperative pelvic radiation in stage IV rectal cancer after resection of primary tumor
title_full_unstemmed The role of postoperative pelvic radiation in stage IV rectal cancer after resection of primary tumor
title_short The role of postoperative pelvic radiation in stage IV rectal cancer after resection of primary tumor
title_sort role of postoperative pelvic radiation in stage iv rectal cancer after resection of primary tumor
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546289/
https://www.ncbi.nlm.nih.gov/pubmed/23346540
http://dx.doi.org/10.3857/roj.2012.30.4.205
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