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Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates

Imbalances in GABA (γ-aminobutyric acid) homoeostasis underlie psychiatric and movement disorders. The ability of the 65 kDa isoform of GAD (glutamic acid decarboxylase), GAD65, to control synaptic GABA levels is influenced through its capacity to auto-inactivate. In contrast, the GAD67 isoform is c...

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Detalles Bibliográficos
Autores principales:	Langendorf, Christopher G., Tuck, Kellie L., Key, Trevor L. G., Fenalti, Gustavo, Pike, Robert N., Rosado, Carlos J., Wong, Anders S. M., Buckle, Ashley M., Law, Ruby H. P., Whisstock, James C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2013
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546353/ https://www.ncbi.nlm.nih.gov/pubmed/23126365 http://dx.doi.org/10.1042/BSR20120111

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