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Identifying combined design and analysis procedures in two-stage trials with a binary end point
Two-stage trial designs provide the flexibility to stop early for efficacy or futility and are popular because they have a smaller sample size on average than a traditional trial has with the same type I and II error rates. This makes them financially attractive but also has the ethical benefit of r...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Blackwell Publishing Ltd
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546375/ https://www.ncbi.nlm.nih.gov/pubmed/22786815 http://dx.doi.org/10.1002/sim.5468 |