Protein Kinase C-β-Dependent Activation of NF-κB in Stromal Cells Is Indispensable for the Survival of Chronic Lymphocytic Leukemia B Cells In Vivo

Tumor cell survival critically depends on heterotypic communication with benign cells in the microenvironment. Here, we describe a survival signaling pathway activated in stromal cells by contact to B cells from patients with chronic lymphocytic leukemia (CLL). The expression of protein kinase C (PK...

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Detalles Bibliográficos
Autores principales: Lutzny, Gloria, Kocher, Thomas, Schmidt-Supprian, Marc, Rudelius, Martina, Klein-Hitpass, Ludger, Finch, Andrew J., Dürig, Jan, Wagner, Michaela, Haferlach, Claudia, Kohlmann, Alexander, Schnittger, Susanne, Seifert, Marc, Wanninger, Stefan, Zaborsky, Nadja, Oostendorp, Robert, Ruland, Jürgen, Leitges, Michael, Kuhnt, Toni, Schäfer, Yvonne, Lampl, Benedikt, Peschel, Christian, Egle, Alexander, Ringshausen, Ingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546417/
https://www.ncbi.nlm.nih.gov/pubmed/23328482
http://dx.doi.org/10.1016/j.ccr.2012.12.003

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