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Complement Activation and Inhibition in Wound Healing

Complement activation is needed to restore tissue injury; however, inappropriate activation of complement, as seen in chronic wounds can cause cell death and enhance inflammation, thus contributing to further injury and impaired wound healing. Therefore, attenuation of complement activation by speci...

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Detalles Bibliográficos
Autores principales: Cazander, Gwendolyn, Jukema, Gerrolt N., Nibbering, Peter H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546472/
https://www.ncbi.nlm.nih.gov/pubmed/23346185
http://dx.doi.org/10.1155/2012/534291
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author Cazander, Gwendolyn
Jukema, Gerrolt N.
Nibbering, Peter H.
author_facet Cazander, Gwendolyn
Jukema, Gerrolt N.
Nibbering, Peter H.
author_sort Cazander, Gwendolyn
collection PubMed
description Complement activation is needed to restore tissue injury; however, inappropriate activation of complement, as seen in chronic wounds can cause cell death and enhance inflammation, thus contributing to further injury and impaired wound healing. Therefore, attenuation of complement activation by specific inhibitors is considered as an innovative wound care strategy. Currently, the effects of several complement inhibitors, for example, the C3 inhibitor compstatin and several C1 and C5 inhibitors, are under investigation in patients with complement-mediated diseases. Although (pre)clinical research into the effects of these complement inhibitors on wound healing is limited, available data indicate that reduction of complement activation can improve wound healing. Moreover, medicine may take advantage of safe and effective agents that are produced by various microorganisms, symbionts, for example, medicinal maggots, and plants to attenuate complement activation. To conclude, for the development of new wound care strategies, (pre)clinical studies into the roles of complement and the effects of application of complement inhibitors in wound healing are required.
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spelling pubmed-35464722013-01-23 Complement Activation and Inhibition in Wound Healing Cazander, Gwendolyn Jukema, Gerrolt N. Nibbering, Peter H. Clin Dev Immunol Review Article Complement activation is needed to restore tissue injury; however, inappropriate activation of complement, as seen in chronic wounds can cause cell death and enhance inflammation, thus contributing to further injury and impaired wound healing. Therefore, attenuation of complement activation by specific inhibitors is considered as an innovative wound care strategy. Currently, the effects of several complement inhibitors, for example, the C3 inhibitor compstatin and several C1 and C5 inhibitors, are under investigation in patients with complement-mediated diseases. Although (pre)clinical research into the effects of these complement inhibitors on wound healing is limited, available data indicate that reduction of complement activation can improve wound healing. Moreover, medicine may take advantage of safe and effective agents that are produced by various microorganisms, symbionts, for example, medicinal maggots, and plants to attenuate complement activation. To conclude, for the development of new wound care strategies, (pre)clinical studies into the roles of complement and the effects of application of complement inhibitors in wound healing are required. Hindawi Publishing Corporation 2012 2012-12-30 /pmc/articles/PMC3546472/ /pubmed/23346185 http://dx.doi.org/10.1155/2012/534291 Text en Copyright © 2012 Gwendolyn Cazander et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cazander, Gwendolyn
Jukema, Gerrolt N.
Nibbering, Peter H.
Complement Activation and Inhibition in Wound Healing
title Complement Activation and Inhibition in Wound Healing
title_full Complement Activation and Inhibition in Wound Healing
title_fullStr Complement Activation and Inhibition in Wound Healing
title_full_unstemmed Complement Activation and Inhibition in Wound Healing
title_short Complement Activation and Inhibition in Wound Healing
title_sort complement activation and inhibition in wound healing
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546472/
https://www.ncbi.nlm.nih.gov/pubmed/23346185
http://dx.doi.org/10.1155/2012/534291
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