Targeted Amino Acid Substitutions Impair Streptolysin O Toxicity and Group A Streptococcus Virulence

Streptolysin O is a potent pore-forming toxin produced by group A Streptococcus. The aims of the present study were to dissect the relative contributions of different structural domains of the protein to hemolytic activity, to obtain a detoxified form of streptolysin O amenable to human vaccine form...

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Detalles Bibliográficos
Autores principales: Chiarot, Emiliano, Faralla, Cristina, Chiappini, Nico, Tuscano, Giovanna, Falugi, Fabiana, Gambellini, Gabriella, Taddei, Annarita, Capo, Sabrina, Cartocci, Elena, Veggi, Daniele, Corrado, Alessia, Mangiavacchi, Simona, Tavarini, Simona, Scarselli, Maria, Janulczyk, Robert, Grandi, Guido, Margarit, Immaculada, Bensi, Giuliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546560/
https://www.ncbi.nlm.nih.gov/pubmed/23300245
http://dx.doi.org/10.1128/mBio.00387-12

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