MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer

MicroRNAs are noncoding RNA molecules of 18–25 nucleotides that regulate gene expression at the post-transcriptional levels. Recent data revealed that miR-218 played key roles in tumor metastasis. Here, we described the regulation and function of miR-218 in cervical cancer. Overexpression of miR-218...

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Detalles Bibliográficos
Autores principales: Li, Jiarui, Ping, Zhang, Ning, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546678/
https://www.ncbi.nlm.nih.gov/pubmed/23443110
http://dx.doi.org/10.3390/ijms131216053
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author Li, Jiarui
Ping, Zhang
Ning, Hui
author_facet Li, Jiarui
Ping, Zhang
Ning, Hui
author_sort Li, Jiarui
collection PubMed
description MicroRNAs are noncoding RNA molecules of 18–25 nucleotides that regulate gene expression at the post-transcriptional levels. Recent data revealed that miR-218 played key roles in tumor metastasis. Here, we described the regulation and function of miR-218 in cervical cancer. Overexpression of miR-218 reduced the proliferation of the human cervical cancer cell line HeLa and induced cell apoptosis through the AKT-mTOR signaling pathway. In addition, it forced expression of miR-218 suppressed tumor growth in the orthotopic mouse model of HeLa cells. Furthermore, miR-218 increased chemosensitivity to cisplatin (CDDP) in vitro. Our results indicated that targeting miR-218 may provide a strategy for blocking the development of cervical cancer.
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spelling pubmed-35466782013-01-23 MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer Li, Jiarui Ping, Zhang Ning, Hui Int J Mol Sci Article MicroRNAs are noncoding RNA molecules of 18–25 nucleotides that regulate gene expression at the post-transcriptional levels. Recent data revealed that miR-218 played key roles in tumor metastasis. Here, we described the regulation and function of miR-218 in cervical cancer. Overexpression of miR-218 reduced the proliferation of the human cervical cancer cell line HeLa and induced cell apoptosis through the AKT-mTOR signaling pathway. In addition, it forced expression of miR-218 suppressed tumor growth in the orthotopic mouse model of HeLa cells. Furthermore, miR-218 increased chemosensitivity to cisplatin (CDDP) in vitro. Our results indicated that targeting miR-218 may provide a strategy for blocking the development of cervical cancer. Molecular Diversity Preservation International (MDPI) 2012-11-28 /pmc/articles/PMC3546678/ /pubmed/23443110 http://dx.doi.org/10.3390/ijms131216053 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Li, Jiarui
Ping, Zhang
Ning, Hui
MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer
title MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer
title_full MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer
title_fullStr MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer
title_full_unstemmed MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer
title_short MiR-218 Impairs Tumor Growth and Increases Chemo-Sensitivity to Cisplatin in Cervical Cancer
title_sort mir-218 impairs tumor growth and increases chemo-sensitivity to cisplatin in cervical cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546678/
https://www.ncbi.nlm.nih.gov/pubmed/23443110
http://dx.doi.org/10.3390/ijms131216053
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AT pingzhang mir218impairstumorgrowthandincreaseschemosensitivitytocisplatinincervicalcancer
AT ninghui mir218impairstumorgrowthandincreaseschemosensitivitytocisplatinincervicalcancer

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