Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities

Four new endiandric acid analogues, tsangibeilin C (1), tsangibeilin D (2), tricyclotsangibeilin (3) and endiandric acid M (4), one new lignan, beilschminol B (5) and two new sesquiterpenes, (+)-5-hydroxybarbatenal (6) and (4R,5R)-4,5-dihydroxycaryophyll-8(13)-ene (7), together with four known compo...

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Autores principales: Huang, Yun-Ting, Chang, Hsun-Shuo, Wang, Guei-Jane, Lin, Chu-Hung, Chen, Ih-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546699/
https://www.ncbi.nlm.nih.gov/pubmed/23208379
http://dx.doi.org/10.3390/ijms131216430
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author Huang, Yun-Ting
Chang, Hsun-Shuo
Wang, Guei-Jane
Lin, Chu-Hung
Chen, Ih-Sheng
author_facet Huang, Yun-Ting
Chang, Hsun-Shuo
Wang, Guei-Jane
Lin, Chu-Hung
Chen, Ih-Sheng
author_sort Huang, Yun-Ting
collection PubMed
description Four new endiandric acid analogues, tsangibeilin C (1), tsangibeilin D (2), tricyclotsangibeilin (3) and endiandric acid M (4), one new lignan, beilschminol B (5) and two new sesquiterpenes, (+)-5-hydroxybarbatenal (6) and (4R,5R)-4,5-dihydroxycaryophyll-8(13)-ene (7), together with four known compounds (8–11), were isolated from the roots of Beilschmiedia tsangii (Lauraceae). The structures of 1–7 were determined by spectroscopic techniques. Among the isolates, endiandric acid M (4) exhibited moderate iNOS inhibitory activity, with an IC(50) value of 31.70 μM.
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spelling pubmed-35466992013-01-23 Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities Huang, Yun-Ting Chang, Hsun-Shuo Wang, Guei-Jane Lin, Chu-Hung Chen, Ih-Sheng Int J Mol Sci Article Four new endiandric acid analogues, tsangibeilin C (1), tsangibeilin D (2), tricyclotsangibeilin (3) and endiandric acid M (4), one new lignan, beilschminol B (5) and two new sesquiterpenes, (+)-5-hydroxybarbatenal (6) and (4R,5R)-4,5-dihydroxycaryophyll-8(13)-ene (7), together with four known compounds (8–11), were isolated from the roots of Beilschmiedia tsangii (Lauraceae). The structures of 1–7 were determined by spectroscopic techniques. Among the isolates, endiandric acid M (4) exhibited moderate iNOS inhibitory activity, with an IC(50) value of 31.70 μM. Molecular Diversity Preservation International (MDPI) 2012-12-03 /pmc/articles/PMC3546699/ /pubmed/23208379 http://dx.doi.org/10.3390/ijms131216430 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Huang, Yun-Ting
Chang, Hsun-Shuo
Wang, Guei-Jane
Lin, Chu-Hung
Chen, Ih-Sheng
Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities
title Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities
title_full Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities
title_fullStr Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities
title_full_unstemmed Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities
title_short Secondary Metabolites from the Roots of Beilschmiedia tsangii and Their Anti-Inflammatory Activities
title_sort secondary metabolites from the roots of beilschmiedia tsangii and their anti-inflammatory activities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546699/
https://www.ncbi.nlm.nih.gov/pubmed/23208379
http://dx.doi.org/10.3390/ijms131216430
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