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Expression of novel tumor markers of pancreatic adenocarcinomas in intrahepatic cholangiocarcinomas
Intrahepatic cholangiocarcinomas (IHCCs) are morphologically and biologically similar to pancreatic ductal adenocarcinomas (PDACs), so newly identified PDAC-associated genes or proteins could provide clues for screening novel biomarkers for IHCC. In this study, the expression of three novel PDAC tum...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546755/ https://www.ncbi.nlm.nih.gov/pubmed/23341740 http://dx.doi.org/10.2147/OTT.S39646 |
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author | Zong, Meijuan Jia, Lei Li, Liang |
author_facet | Zong, Meijuan Jia, Lei Li, Liang |
author_sort | Zong, Meijuan |
collection | PubMed |
description | Intrahepatic cholangiocarcinomas (IHCCs) are morphologically and biologically similar to pancreatic ductal adenocarcinomas (PDACs), so newly identified PDAC-associated genes or proteins could provide clues for screening novel biomarkers for IHCC. In this study, the expression of three novel PDAC tumor markers (T-box transcription factor-4 [TBX4], heat shock protein-60 [HSP60], and Parkinson protein-7 [DJ-1]) identified in previous proteomic studies in IHCC tumors were immunohistochemically detected. The current study confirmed that three novel pancreatic cancer biomarkers TBX4, HSP60, and DJ-1 were also overexpressed in IHCC tumors, but with a relatively lower expression level than PDAC. No significant association was found between tumor marker expression and the clinicopathological characteristics of IHCC patients except that TBX4 expression correlated with tumor grades. Moreover, DJ-1 was demonstrated to be an independent prognostic factor for these patients. The current findings suggest that DJ-1 might play an important role in the malignant progression of IHCC, and its exact mechanism during IHCC progression deserves further investigation. |
format | Online Article Text |
id | pubmed-3546755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-35467552013-01-22 Expression of novel tumor markers of pancreatic adenocarcinomas in intrahepatic cholangiocarcinomas Zong, Meijuan Jia, Lei Li, Liang Onco Targets Ther Short Report Intrahepatic cholangiocarcinomas (IHCCs) are morphologically and biologically similar to pancreatic ductal adenocarcinomas (PDACs), so newly identified PDAC-associated genes or proteins could provide clues for screening novel biomarkers for IHCC. In this study, the expression of three novel PDAC tumor markers (T-box transcription factor-4 [TBX4], heat shock protein-60 [HSP60], and Parkinson protein-7 [DJ-1]) identified in previous proteomic studies in IHCC tumors were immunohistochemically detected. The current study confirmed that three novel pancreatic cancer biomarkers TBX4, HSP60, and DJ-1 were also overexpressed in IHCC tumors, but with a relatively lower expression level than PDAC. No significant association was found between tumor marker expression and the clinicopathological characteristics of IHCC patients except that TBX4 expression correlated with tumor grades. Moreover, DJ-1 was demonstrated to be an independent prognostic factor for these patients. The current findings suggest that DJ-1 might play an important role in the malignant progression of IHCC, and its exact mechanism during IHCC progression deserves further investigation. Dove Medical Press 2013-01-11 /pmc/articles/PMC3546755/ /pubmed/23341740 http://dx.doi.org/10.2147/OTT.S39646 Text en © 2013 Zong et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Short Report Zong, Meijuan Jia, Lei Li, Liang Expression of novel tumor markers of pancreatic adenocarcinomas in intrahepatic cholangiocarcinomas |
title | Expression of novel tumor markers of pancreatic adenocarcinomas in intrahepatic cholangiocarcinomas |
title_full | Expression of novel tumor markers of pancreatic adenocarcinomas in intrahepatic cholangiocarcinomas |
title_fullStr | Expression of novel tumor markers of pancreatic adenocarcinomas in intrahepatic cholangiocarcinomas |
title_full_unstemmed | Expression of novel tumor markers of pancreatic adenocarcinomas in intrahepatic cholangiocarcinomas |
title_short | Expression of novel tumor markers of pancreatic adenocarcinomas in intrahepatic cholangiocarcinomas |
title_sort | expression of novel tumor markers of pancreatic adenocarcinomas in intrahepatic cholangiocarcinomas |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546755/ https://www.ncbi.nlm.nih.gov/pubmed/23341740 http://dx.doi.org/10.2147/OTT.S39646 |
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