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Buccal midazolam for pediatric convulsive seizures: efficacy, safety, and patient acceptability

Prolonged seizures and status epilepticus are a common acute neurological presentation in pediatric practice. As a result, there is a need for effective and safe medications that can be delivered to convulsing children to effect rapid seizure termination both in hospital and community settings. The...

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Detalles Bibliográficos
Autor principal: Anderson, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546805/
https://www.ncbi.nlm.nih.gov/pubmed/23341735
http://dx.doi.org/10.2147/PPA.S39233
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author Anderson, Mark
author_facet Anderson, Mark
author_sort Anderson, Mark
collection PubMed
description Prolonged seizures and status epilepticus are a common acute neurological presentation in pediatric practice. As a result, there is a need for effective and safe medications that can be delivered to convulsing children to effect rapid seizure termination both in hospital and community settings. The challenges of achieving intravenous access, particularly in young children, mandate alternative routes of administration for these drugs. Over the last ten years, midazolam delivered via the buccal mucosa has been demonstrated to be efficacious, safe, and acceptable to children and their caregivers, and a formulation has recently been licensed for use in Europe. The aim of this article is to review the clinical pharmacology with respect to these issues.
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spelling pubmed-35468052013-01-22 Buccal midazolam for pediatric convulsive seizures: efficacy, safety, and patient acceptability Anderson, Mark Patient Prefer Adherence Review Prolonged seizures and status epilepticus are a common acute neurological presentation in pediatric practice. As a result, there is a need for effective and safe medications that can be delivered to convulsing children to effect rapid seizure termination both in hospital and community settings. The challenges of achieving intravenous access, particularly in young children, mandate alternative routes of administration for these drugs. Over the last ten years, midazolam delivered via the buccal mucosa has been demonstrated to be efficacious, safe, and acceptable to children and their caregivers, and a formulation has recently been licensed for use in Europe. The aim of this article is to review the clinical pharmacology with respect to these issues. Dove Medical Press 2013-01-10 /pmc/articles/PMC3546805/ /pubmed/23341735 http://dx.doi.org/10.2147/PPA.S39233 Text en © 2013 Anderson, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Anderson, Mark
Buccal midazolam for pediatric convulsive seizures: efficacy, safety, and patient acceptability
title Buccal midazolam for pediatric convulsive seizures: efficacy, safety, and patient acceptability
title_full Buccal midazolam for pediatric convulsive seizures: efficacy, safety, and patient acceptability
title_fullStr Buccal midazolam for pediatric convulsive seizures: efficacy, safety, and patient acceptability
title_full_unstemmed Buccal midazolam for pediatric convulsive seizures: efficacy, safety, and patient acceptability
title_short Buccal midazolam for pediatric convulsive seizures: efficacy, safety, and patient acceptability
title_sort buccal midazolam for pediatric convulsive seizures: efficacy, safety, and patient acceptability
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546805/
https://www.ncbi.nlm.nih.gov/pubmed/23341735
http://dx.doi.org/10.2147/PPA.S39233
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