Gene therapy for colorectal cancer by an oncolytic adenovirus that targets loss of the insulin-like growth factor 2 imprinting system

BACKGROUND: Colorectal cancer is one of the most common malignant tumors worldwide. Loss of imprinting (LOI) of the insulin-like growth factor 2 (IGF2) gene is an epigenetic abnormality observed in human colorectal neoplasms. Our aim was to investigate the feasibility of using the IGF2 imprinting sy...

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Detalles Bibliográficos
Autores principales: Nie, Zhen-Lin, Pan, Yu-Qin, He, Bang-Shun, Gu, Ling, Chen, Li-Ping, Li, Rui, Xu, Ye-Qiong, Gao, Tian-Yi, Song, Guo-Qi, Hoffman, Andrew R, Wang, Shu-Kui, Hu, Ji-Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546838/
https://www.ncbi.nlm.nih.gov/pubmed/23171475
http://dx.doi.org/10.1186/1476-4598-11-86

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