Using BAC transgenesis in zebrafish to identify regulatory sequences of the amyloid precursor protein gene in humans

BACKGROUND: Non-coding DNA in and around the human Amyloid Precursor Protein (APP) gene that is central to Alzheimer’s disease (AD) shares little sequence similarity with that of appb in zebrafish. Identifying DNA domains regulating expression of the gene in such situations becomes a challenge. Taki...

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Detalles Bibliográficos
Autores principales: Shakes, Leighcraft A, Du, Hansen, Wolf, Hope M, Hatcher, Charles, Norford, Derek C, Precht, Patricia, Sen, Ranjan, Chatterjee, Pradeep K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546842/
https://www.ncbi.nlm.nih.gov/pubmed/22947103
http://dx.doi.org/10.1186/1471-2164-13-451

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