Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene

BACKGROUND: Oxidative Stress contributes to the pathogenesis of many diseases. The NRF2/KEAP1 axis is a key transcriptional regulator of the anti-oxidant response in cells. Nrf2 knockout mice have implicated this pathway in regulating inflammatory airway diseases such as asthma and COPD. To better u...

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Detalles Bibliográficos
Autores principales: Fourtounis, Jimmy, Wang, I-Ming, Mathieu, Marie-Claude, Claveau, David, Loo, Tenneille, Jackson, Aimee L, Peters, Mette A, Therien, Alex G, Boie, Yves, Crackower, Michael A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546844/
https://www.ncbi.nlm.nih.gov/pubmed/23061798
http://dx.doi.org/10.1186/1465-9921-13-92

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