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Intracardiac injection of a capsid-modified Ad5/35 results in decreased heart toxicity when compared to standard Ad5

BACKGROUND: Clinical gene therapy trials for cardiovascular diseases have demonstrated the crucial role of efficient gene delivery and transfection technologies in achieving clinically relevant results. We hypothesized that the use of tropism-modified adenoviruses would improve transduction efficacy...

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Detalles Bibliográficos
Autores principales:	Toivonen, Raine, Koskenvuo, Juha, Merentie, Mari, Söderström, Mirva, Ylä-Herttuala, Seppo, Savontaus, Mikko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546865/ https://www.ncbi.nlm.nih.gov/pubmed/23190872 http://dx.doi.org/10.1186/1743-422X-9-296

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