Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

BACKGROUND: Parkinson’s disease (PD) is a neurodegenerative disease characterized by selective degeneration of dopaminergic neurons in the substantia nigra (SN). The familial form of PD, PARK2, is caused by mutations in the parkin gene. parkin-knockout mouse models show some abnormalities, but they...

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Detalles Bibliográficos
Autores principales: Imaizumi, Yoichi, Okada, Yohei, Akamatsu, Wado, Koike, Masato, Kuzumaki, Naoko, Hayakawa, Hideki, Nihira, Tomoko, Kobayashi, Tetsuro, Ohyama, Manabu, Sato, Shigeto, Takanashi, Masashi, Funayama, Manabu, Hirayama, Akiyoshi, Soga, Tomoyoshi, Hishiki, Takako, Suematsu, Makoto, Yagi, Takuya, Ito, Daisuke, Kosakai, Arifumi, Hayashi, Kozo, Shouji, Masanobu, Nakanishi, Atsushi, Suzuki, Norihiro, Mizuno, Yoshikuni, Mizushima, Noboru, Amagai, Masayuki, Uchiyama, Yasuo, Mochizuki, Hideki, Hattori, Nobutaka, Okano, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546866/
https://www.ncbi.nlm.nih.gov/pubmed/23039195
http://dx.doi.org/10.1186/1756-6606-5-35

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