Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H ß-synuclein

BACKGROUND: Axonopathy is critical in the early pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Axonal swellings such as globules and spheroids are a distinct feature of axonopathy and our recent study showed that transgenic (tg) mi...

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Detalles Bibliográficos
Autores principales: Sekigawa, Akio, Fujita, Masayo, Sekiyama, Kazunari, Takamatsu, Yoshiki, Hatano, Taku, Rockenstein, Edward, La Spada, Albert R, Masliah, Eliezer, Hashimoto, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546907/
https://www.ncbi.nlm.nih.gov/pubmed/23013868
http://dx.doi.org/10.1186/1756-6606-5-34

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