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Association between GRN rs5848 Polymorphism and Parkinson′s Disease in Taiwanese Population
A single nucleotide polymorphism GRN rs5848 (3′UTR+78 C>T) was reported to alter the risk for frontotemporal lobar degeneration. Herein, we investigated the effect of GRN rs5848 on the risk of Parkinson’s disease (PD) by genotyping 573 Taiwanese patients with PD and 490 age-matched control subjec...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546937/ https://www.ncbi.nlm.nih.gov/pubmed/23342160 http://dx.doi.org/10.1371/journal.pone.0054448 |
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author | Chang, Kuo-Hsuan Chen, Chiung-Mei Chen, Yi-Chun Hsiao, Ya-Chin Huang, Chin-Chang Kuo, Hung-Chou Hsu, Hsuan-Chu Lee-Chen, Guey-Jen Wu, Yih-Ru |
author_facet | Chang, Kuo-Hsuan Chen, Chiung-Mei Chen, Yi-Chun Hsiao, Ya-Chin Huang, Chin-Chang Kuo, Hung-Chou Hsu, Hsuan-Chu Lee-Chen, Guey-Jen Wu, Yih-Ru |
author_sort | Chang, Kuo-Hsuan |
collection | PubMed |
description | A single nucleotide polymorphism GRN rs5848 (3′UTR+78 C>T) was reported to alter the risk for frontotemporal lobar degeneration. Herein, we investigated the effect of GRN rs5848 on the risk of Parkinson’s disease (PD) by genotyping 573 Taiwanese patients with PD and 490 age-matched control subjects. Compared to subjects with CC genotype, those with TT genotype had a 1.58-fold increased risk of PD (95% CI: 1.77∼2.34, P = 0.021). PD patients demonstrate a higher frequency of T allele (37.2%) than controls (32.2%; odds ratio [OR] = 1.24, 95% CI: 1.04∼1.49, P = 0.017). This susceptibility was particularly observed in female subjects, in which TT genotype had a 2.16-fold increased risk of PD as compared with controls(95% CI: 1.24∼3.78, P = 0.006). The frequency of T allele (39.3%) in female PD patients was higher than in female control subjects (31.1%; OR = 1.43, CI: 1.11∼1.87, P = 0.007). No association was observed between GRN rs5848 and susceptibility in male subjects. These findings show that the GRN rs5848 TT genotype and T allele are risk factors for female Taiwanese patients with PD. |
format | Online Article Text |
id | pubmed-3546937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-35469372013-01-22 Association between GRN rs5848 Polymorphism and Parkinson′s Disease in Taiwanese Population Chang, Kuo-Hsuan Chen, Chiung-Mei Chen, Yi-Chun Hsiao, Ya-Chin Huang, Chin-Chang Kuo, Hung-Chou Hsu, Hsuan-Chu Lee-Chen, Guey-Jen Wu, Yih-Ru PLoS One Research Article A single nucleotide polymorphism GRN rs5848 (3′UTR+78 C>T) was reported to alter the risk for frontotemporal lobar degeneration. Herein, we investigated the effect of GRN rs5848 on the risk of Parkinson’s disease (PD) by genotyping 573 Taiwanese patients with PD and 490 age-matched control subjects. Compared to subjects with CC genotype, those with TT genotype had a 1.58-fold increased risk of PD (95% CI: 1.77∼2.34, P = 0.021). PD patients demonstrate a higher frequency of T allele (37.2%) than controls (32.2%; odds ratio [OR] = 1.24, 95% CI: 1.04∼1.49, P = 0.017). This susceptibility was particularly observed in female subjects, in which TT genotype had a 2.16-fold increased risk of PD as compared with controls(95% CI: 1.24∼3.78, P = 0.006). The frequency of T allele (39.3%) in female PD patients was higher than in female control subjects (31.1%; OR = 1.43, CI: 1.11∼1.87, P = 0.007). No association was observed between GRN rs5848 and susceptibility in male subjects. These findings show that the GRN rs5848 TT genotype and T allele are risk factors for female Taiwanese patients with PD. Public Library of Science 2013-01-16 /pmc/articles/PMC3546937/ /pubmed/23342160 http://dx.doi.org/10.1371/journal.pone.0054448 Text en © 2013 Chang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Chang, Kuo-Hsuan Chen, Chiung-Mei Chen, Yi-Chun Hsiao, Ya-Chin Huang, Chin-Chang Kuo, Hung-Chou Hsu, Hsuan-Chu Lee-Chen, Guey-Jen Wu, Yih-Ru Association between GRN rs5848 Polymorphism and Parkinson′s Disease in Taiwanese Population |
title | Association between GRN rs5848 Polymorphism and Parkinson′s Disease in Taiwanese Population |
title_full | Association between GRN rs5848 Polymorphism and Parkinson′s Disease in Taiwanese Population |
title_fullStr | Association between GRN rs5848 Polymorphism and Parkinson′s Disease in Taiwanese Population |
title_full_unstemmed | Association between GRN rs5848 Polymorphism and Parkinson′s Disease in Taiwanese Population |
title_short | Association between GRN rs5848 Polymorphism and Parkinson′s Disease in Taiwanese Population |
title_sort | association between grn rs5848 polymorphism and parkinson′s disease in taiwanese population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546937/ https://www.ncbi.nlm.nih.gov/pubmed/23342160 http://dx.doi.org/10.1371/journal.pone.0054448 |
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