Cargando…

Blocking the Class I Histone Deacetylase Ameliorates Renal Fibrosis and Inhibits Renal Fibroblast Activation via Modulating TGF-Beta and EGFR Signaling

BACKGROUND: Histone deacetylase (HDAC) inhibitors are promising anti-fibrosis drugs; however, nonselective inhibition of class I and class II HDACs does not allow a detailed elucidation of the individual HDAC functions in renal fibrosis. In this study, we investigated the effect of MS-275, a selecti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Na, He, Song, Ma, Li, Ponnusamy, Murugavel, Tang, Jinhua, Tolbert, Evelyn, Bayliss, George, Zhao, Ting C., Yan, Haidong, Zhuang, Shougang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546966/ https://www.ncbi.nlm.nih.gov/pubmed/23342059 http://dx.doi.org/10.1371/journal.pone.0054001

Ejemplares similares

Src inhibition blocks renal interstitial fibroblast activation and ameliorates renal fibrosis
por: Yan, Yanli, et al.
Publicado: (2016)

Class IIa histone deacetylase inhibition ameliorates acute kidney injury by suppressing renal tubular cell apoptosis and enhancing autophagy and proliferation
por: Li, Jialu, et al.
Publicado: (2022)

Histone demethylase JMJD3 protects against renal fibrosis by suppressing TGFβ and Notch signaling and preserving PTEN expression
por: Yu, Chao, et al.
Publicado: (2021)

Pharmacological targeting of BET proteins inhibits renal fibroblast activation and alleviates renal fibrosis
por: Xiong, Chongxiang, et al.
Publicado: (2016)

EGFR signaling in renal fibrosis
por: Zhuang, Shougang, et al.
Publicado: (2014)

Histone Acetylation and Modifiers in Renal Fibrosis
por: Shen, Fengchen, et al.
Publicado: (2022)

Treatment of chronic kidney diseases with histone deacetylase inhibitors
por: Liu, Na, et al.
Publicado: (2015)

Irisin Ameliorates Hypoxia/Reoxygenation-Induced Injury through Modulation of Histone Deacetylase 4
por: Zhao, Yu Tina, et al.
Publicado: (2016)

The Role and Mechanism of Histone Deacetylases in Acute Kidney Injury
por: Zhou, Xun, et al.
Publicado: (2021)

Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer
por: Fritzsche, Florian R, et al.
Publicado: (2008)

Protein arginine methyltransferases in renal development, injury, repair, and fibrosis
por: Yu, Jianjun, et al.
Publicado: (2023)

Histone methyltransferase MLL1 drives renal tubular cell apoptosis by p53-dependent repression of E-cadherin during cisplatin-induced acute kidney injury
por: Zhang, Chunyun, et al.
Publicado: (2022)

Selective Inhibition of Histone Deacetylase Class IIa With MC1568 Ameliorates Podocyte Injury
por: He, Xu, et al.
Publicado: (2022)

Critical Functions of Histone Deacetylases (HDACs) in Modulating Inflammation Associated with Cardiovascular Diseases
por: Kulthinee, Supaporn, et al.
Publicado: (2022)

Suramin Alleviates Glomerular Injury and Inflammation in the Remnant Kidney
por: Liu, Na, et al.
Publicado: (2012)

Molecular mechanisms of histone deacetylases and inhibitors in renal fibrosis progression
por: Wang, Jiayu, et al.
Publicado: (2022)

Reduction of class I histone deacetylases ameliorates ER‐mitochondria cross‐talk in Alzheimer's disease
por: Marinho, Daniela, et al.
Publicado: (2023)

Class I Histone Deacetylase Inhibitor Entinostat Suppresses Regulatory T Cells and Enhances Immunotherapies in Renal and Prostate Cancer Models
por: Shen, Li, et al.
Publicado: (2012)

Inhibition of histone deacetylase 1 ameliorates renal tubulointerstitial fibrosis via modulation of inflammation and extracellular matrix gene transcription in mice
por: Nguyễn-Thanh, Tùng, et al.
Publicado: (2018)

Class I histone deacetylases (HDAC1–3) are histone lysine delactylases
por: Moreno-Yruela, Carlos, et al.
Publicado: (2022)

Histone Deacetylase 11 Contributes to Renal Fibrosis by Repressing KLF15 Transcription
por: Mao, Lei, et al.
Publicado: (2020)

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma
por: Phimmachanh, Monica, et al.
Publicado: (2020)

Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice
por: Chen, Youfang, et al.
Publicado: (2015)

Transcription Regulation by Class III Histone Deacetylases (HDACs)—Sirtuins
por: Dai, Yan, et al.
Publicado: (2008)

Eloquent silence: developmental functions of Class I histone deacetylases
por: Cunliffe, Vincent T
Publicado: (2008)

Class IIa Histone Deacetylases Are Conserved Regulators of Circadian Function
por: Fogg, Paul C. M., et al.
Publicado: (2014)

A Class 1 Histone Deacetylase with Potential as an Antifungal Target
por: Bauer, Ingo, et al.
Publicado: (2016)

The class II histone deacetylases as therapeutic targets for Parkinson’s disease
por: Mazzocchi, Martina, et al.
Publicado: (2020)

Targeting Class I Histone Deacetylases in Human Uterine Leiomyosarcoma
por: Yang, Qiwei, et al.
Publicado: (2022)

The role of class IIa histone deacetylases in regulating endothelial function
por: Shen, Zexu, et al.
Publicado: (2023)

Medicinal chemistry advances in targeting class I histone deacetylases
por: Abdallah, Diaaeldin I., et al.
Publicado: (2023)

Class I histone deacetylase complex: Structure and functional correlates
por: Wang, Xiao, et al.
Publicado: (2023)

Histone deacetylase inhibitor, CG200745 attenuates renal fibrosis in obstructive kidney disease
por: Choi, Hong Sang, et al.
Publicado: (2018)

Inflammation and Oxidative Stress in Obesity-Related Glomerulopathy
por: Tang, Jinhua, et al.
Publicado: (2012)

Histone deacetylase inhibitor givinostat has ameliorative effect in the colitis model
por: Dibekoğlu, Cengiz, et al.
Publicado: (2022)

Nuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogramming
por: Luo, Zhiwei, et al.
Publicado: (2019)

Roles and Targets of Class I and IIa Histone Deacetylases in Cardiac Hypertrophy
por: Kee, Hae Jin, et al.
Publicado: (2011)

Electrocardiographic effects of class 1 selective histone deacetylase inhibitor romidepsin
por: Sager, Philip T, et al.
Publicado: (2015)

Subcellular Localization of Class I Histone Deacetylases in the Developing Xenopus tectum
por: Guo, Xia, et al.
Publicado: (2016)

Use of class I histone deacetylase inhibitor romidepsin in combination regimens
por: Petrich, Adam, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_idmg7gnf0vh6m2bn3gen3ohk6v