Mitochondrial DNA Damage and Dysfunction, and Oxidative Stress Are Associated with Endoplasmic Reticulum Stress, Protein Degradation and Apoptosis in High Fat Diet-Induced Insulin Resistance Mice

BACKGROUND: Recent studies showed a link between a high fat diet (HFD)-induced obesity and lipid accumulation in non-adipose tissues, such as skeletal muscle and liver, and insulin resistance (IR). Although the mechanisms responsible for IR in those tissues are different, oxidative stress and mitoch...

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Detalles Bibliográficos
Autores principales: Yuzefovych, Larysa V., Musiyenko, Sergiy I., Wilson, Glenn L., Rachek, Lyudmila I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546973/
https://www.ncbi.nlm.nih.gov/pubmed/23342074
http://dx.doi.org/10.1371/journal.pone.0054059

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