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Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis
Graves' disease (GD) is a leading cause of hyperthyroidism, which affects 1.0-1.6% of the general population. Previous studies reported a higher GD prevalence in Asian populations compared to Caucasian populations. The etiology of GD involves complex interactions between predisposing genes and...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547214/ https://www.ncbi.nlm.nih.gov/pubmed/23329888 http://dx.doi.org/10.7150/ijms.5158 |
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author | Li, Yiping Yao, Yufeng Yang, Man Shi, Li Li, Xianli Yang, Ying Zhang, Ying Xiao, Chunjie |
author_facet | Li, Yiping Yao, Yufeng Yang, Man Shi, Li Li, Xianli Yang, Ying Zhang, Ying Xiao, Chunjie |
author_sort | Li, Yiping |
collection | PubMed |
description | Graves' disease (GD) is a leading cause of hyperthyroidism, which affects 1.0-1.6% of the general population. Previous studies reported a higher GD prevalence in Asian populations compared to Caucasian populations. The etiology of GD involves complex interactions between predisposing genes and environmental triggers. Genetic studies have shown that the human leukocyte antigen (HLA) is an important candidate genetic region associated with GD in Asian populations. However, the results were inconsistent and inconclusive. Here, we performed a meta-analysis to evaluate the role of the HLA-B*46 allele in GD in Asian populations. A total of 14 case-controlled studies on the association of the HLA-B*46 allele in 1743 GD patients and 5689 controls were included. Our results showed a trend toward an increased risk of GD in HLA-B*46-positive subjects compared to those HLA-B*46-negative (OR = 2.48; 95% CI = 1.96-3.13, P < 0.01). However, there were some limitations to the current meta-analysis, such as heterogeneity (P(heterogeneity )< 0.01 and I(2 )= 68.0%) or the different typing methods (serological and genotyping methods). The meta-analysis indicated that the HLA-B*46 allele is a risk factor for GD in Asian populations. Future studies on the role of the HLA-B*46 allele in GD should consider complications such as periodic paralysis, ophthalmopathy and recurrence. |
format | Online Article Text |
id | pubmed-3547214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-35472142013-01-17 Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis Li, Yiping Yao, Yufeng Yang, Man Shi, Li Li, Xianli Yang, Ying Zhang, Ying Xiao, Chunjie Int J Med Sci Research Paper Graves' disease (GD) is a leading cause of hyperthyroidism, which affects 1.0-1.6% of the general population. Previous studies reported a higher GD prevalence in Asian populations compared to Caucasian populations. The etiology of GD involves complex interactions between predisposing genes and environmental triggers. Genetic studies have shown that the human leukocyte antigen (HLA) is an important candidate genetic region associated with GD in Asian populations. However, the results were inconsistent and inconclusive. Here, we performed a meta-analysis to evaluate the role of the HLA-B*46 allele in GD in Asian populations. A total of 14 case-controlled studies on the association of the HLA-B*46 allele in 1743 GD patients and 5689 controls were included. Our results showed a trend toward an increased risk of GD in HLA-B*46-positive subjects compared to those HLA-B*46-negative (OR = 2.48; 95% CI = 1.96-3.13, P < 0.01). However, there were some limitations to the current meta-analysis, such as heterogeneity (P(heterogeneity )< 0.01 and I(2 )= 68.0%) or the different typing methods (serological and genotyping methods). The meta-analysis indicated that the HLA-B*46 allele is a risk factor for GD in Asian populations. Future studies on the role of the HLA-B*46 allele in GD should consider complications such as periodic paralysis, ophthalmopathy and recurrence. Ivyspring International Publisher 2013-01-03 /pmc/articles/PMC3547214/ /pubmed/23329888 http://dx.doi.org/10.7150/ijms.5158 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited. |
spellingShingle | Research Paper Li, Yiping Yao, Yufeng Yang, Man Shi, Li Li, Xianli Yang, Ying Zhang, Ying Xiao, Chunjie Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis |
title | Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis |
title_full | Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis |
title_fullStr | Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis |
title_full_unstemmed | Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis |
title_short | Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis |
title_sort | association between hla-b*46 allele and graves disease in asian populations: a meta-analysis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547214/ https://www.ncbi.nlm.nih.gov/pubmed/23329888 http://dx.doi.org/10.7150/ijms.5158 |
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