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Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis

Graves' disease (GD) is a leading cause of hyperthyroidism, which affects 1.0-1.6% of the general population. Previous studies reported a higher GD prevalence in Asian populations compared to Caucasian populations. The etiology of GD involves complex interactions between predisposing genes and...

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Autores principales: Li, Yiping, Yao, Yufeng, Yang, Man, Shi, Li, Li, Xianli, Yang, Ying, Zhang, Ying, Xiao, Chunjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547214/
https://www.ncbi.nlm.nih.gov/pubmed/23329888
http://dx.doi.org/10.7150/ijms.5158
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author Li, Yiping
Yao, Yufeng
Yang, Man
Shi, Li
Li, Xianli
Yang, Ying
Zhang, Ying
Xiao, Chunjie
author_facet Li, Yiping
Yao, Yufeng
Yang, Man
Shi, Li
Li, Xianli
Yang, Ying
Zhang, Ying
Xiao, Chunjie
author_sort Li, Yiping
collection PubMed
description Graves' disease (GD) is a leading cause of hyperthyroidism, which affects 1.0-1.6% of the general population. Previous studies reported a higher GD prevalence in Asian populations compared to Caucasian populations. The etiology of GD involves complex interactions between predisposing genes and environmental triggers. Genetic studies have shown that the human leukocyte antigen (HLA) is an important candidate genetic region associated with GD in Asian populations. However, the results were inconsistent and inconclusive. Here, we performed a meta-analysis to evaluate the role of the HLA-B*46 allele in GD in Asian populations. A total of 14 case-controlled studies on the association of the HLA-B*46 allele in 1743 GD patients and 5689 controls were included. Our results showed a trend toward an increased risk of GD in HLA-B*46-positive subjects compared to those HLA-B*46-negative (OR = 2.48; 95% CI = 1.96-3.13, P < 0.01). However, there were some limitations to the current meta-analysis, such as heterogeneity (P(heterogeneity )< 0.01 and I(2 )= 68.0%) or the different typing methods (serological and genotyping methods). The meta-analysis indicated that the HLA-B*46 allele is a risk factor for GD in Asian populations. Future studies on the role of the HLA-B*46 allele in GD should consider complications such as periodic paralysis, ophthalmopathy and recurrence.
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spelling pubmed-35472142013-01-17 Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis Li, Yiping Yao, Yufeng Yang, Man Shi, Li Li, Xianli Yang, Ying Zhang, Ying Xiao, Chunjie Int J Med Sci Research Paper Graves' disease (GD) is a leading cause of hyperthyroidism, which affects 1.0-1.6% of the general population. Previous studies reported a higher GD prevalence in Asian populations compared to Caucasian populations. The etiology of GD involves complex interactions between predisposing genes and environmental triggers. Genetic studies have shown that the human leukocyte antigen (HLA) is an important candidate genetic region associated with GD in Asian populations. However, the results were inconsistent and inconclusive. Here, we performed a meta-analysis to evaluate the role of the HLA-B*46 allele in GD in Asian populations. A total of 14 case-controlled studies on the association of the HLA-B*46 allele in 1743 GD patients and 5689 controls were included. Our results showed a trend toward an increased risk of GD in HLA-B*46-positive subjects compared to those HLA-B*46-negative (OR = 2.48; 95% CI = 1.96-3.13, P < 0.01). However, there were some limitations to the current meta-analysis, such as heterogeneity (P(heterogeneity )< 0.01 and I(2 )= 68.0%) or the different typing methods (serological and genotyping methods). The meta-analysis indicated that the HLA-B*46 allele is a risk factor for GD in Asian populations. Future studies on the role of the HLA-B*46 allele in GD should consider complications such as periodic paralysis, ophthalmopathy and recurrence. Ivyspring International Publisher 2013-01-03 /pmc/articles/PMC3547214/ /pubmed/23329888 http://dx.doi.org/10.7150/ijms.5158 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Research Paper
Li, Yiping
Yao, Yufeng
Yang, Man
Shi, Li
Li, Xianli
Yang, Ying
Zhang, Ying
Xiao, Chunjie
Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis
title Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis
title_full Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis
title_fullStr Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis
title_full_unstemmed Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis
title_short Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis
title_sort association between hla-b*46 allele and graves disease in asian populations: a meta-analysis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547214/
https://www.ncbi.nlm.nih.gov/pubmed/23329888
http://dx.doi.org/10.7150/ijms.5158
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