Glycomics using mass spectrometry

Mass spectrometry plays an increasingly important role in structural glycomics. This review provides an overview on currently used mass spectrometric approaches such as the characterization of glycans, the analysis of glycopeptides obtained by proteolytic cleavage of proteins and the analysis of gly...

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Detalles Bibliográficos
Autor principal: Wuhrer, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547245/
https://www.ncbi.nlm.nih.gov/pubmed/22532006
http://dx.doi.org/10.1007/s10719-012-9376-3
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author Wuhrer, Manfred
author_facet Wuhrer, Manfred
author_sort Wuhrer, Manfred
collection PubMed
description Mass spectrometry plays an increasingly important role in structural glycomics. This review provides an overview on currently used mass spectrometric approaches such as the characterization of glycans, the analysis of glycopeptides obtained by proteolytic cleavage of proteins and the analysis of glycosphingolipids. The given examples are demonstrating the application of mass spectrometry to study glycosylation changes associated with congenital disorders of glycosylation, lysosomal storage diseases, autoimmune diseases and cancer.
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spelling pubmed-35472452013-01-17 Glycomics using mass spectrometry Wuhrer, Manfred Glycoconj J Article Mass spectrometry plays an increasingly important role in structural glycomics. This review provides an overview on currently used mass spectrometric approaches such as the characterization of glycans, the analysis of glycopeptides obtained by proteolytic cleavage of proteins and the analysis of glycosphingolipids. The given examples are demonstrating the application of mass spectrometry to study glycosylation changes associated with congenital disorders of glycosylation, lysosomal storage diseases, autoimmune diseases and cancer. Springer US 2012-04-25 2013 /pmc/articles/PMC3547245/ /pubmed/22532006 http://dx.doi.org/10.1007/s10719-012-9376-3 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Wuhrer, Manfred
Glycomics using mass spectrometry
title Glycomics using mass spectrometry
title_full Glycomics using mass spectrometry
title_fullStr Glycomics using mass spectrometry
title_full_unstemmed Glycomics using mass spectrometry
title_short Glycomics using mass spectrometry
title_sort glycomics using mass spectrometry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547245/
https://www.ncbi.nlm.nih.gov/pubmed/22532006
http://dx.doi.org/10.1007/s10719-012-9376-3
work_keys_str_mv AT wuhrermanfred glycomicsusingmassspectrometry

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