Naphthoquinone Derivatives Exert Their Antitrypanosomal Activity via a Multi-Target Mechanism

BACKGROUND AND METHODOLOGY: Recently, we reported on a new class of naphthoquinone derivatives showing a promising anti-trypanosomatid profile in cell-based experiments. The lead of this series (B6, 2-phenoxy-1,4-naphthoquinone) showed an ED(50) of 80 nM against Trypanosoma brucei rhodesiense, and a...

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Detalles Bibliográficos
Autores principales: Pieretti, Simone, Haanstra, Jurgen R., Mazet, Muriel, Perozzo, Remo, Bergamini, Christian, Prati, Federica, Fato, Romana, Lenaz, Giorgio, Capranico, Giovanni, Brun, Reto, Bakker, Barbara M., Michels, Paul A. M., Scapozza, Leonardo, Bolognesi, Maria Laura, Cavalli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547856/
https://www.ncbi.nlm.nih.gov/pubmed/23350008
http://dx.doi.org/10.1371/journal.pntd.0002012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547856/
https://www.ncbi.nlm.nih.gov/pubmed/23350008
http://dx.doi.org/10.1371/journal.pntd.0002012

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