Stabilization of the Skeletal Muscle Ryanodine Receptor Ion Channel-FKBP12 Complex by the 1,4-Benzothiazepine Derivative S107

Activation of the skeletal muscle ryanodine receptor (RyR1) complex results in the rapid release of Ca(2+) from the sarcoplasmic reticulum and muscle contraction. Dissociation of the small FK506 binding protein 12 subunit (FKBP12) increases RyR1 activity and impairs muscle function. The 1,4-benzothi...

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Detalles Bibliográficos
Autores principales: Mei, Yingwu, Xu, Le, Kramer, Henning F., Tomberlin, Ginger H., Townsend, Claire, Meissner, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547879/
https://www.ncbi.nlm.nih.gov/pubmed/23349825
http://dx.doi.org/10.1371/journal.pone.0054208

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