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Pharmacokinetics and Pharmacodynamics of the Proton Pump Inhibitors
Proton pump inhibitor (PPI) is a prodrug which is activated by acid. Activated PPI binds covalently to the gastric H(+), K(+)-ATPase via disulfide bond. Cys813 is the primary site responsible for the inhibition of acid pump enzyme, where PPIs bind. Omeprazole was the first PPI introduced in market,...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Korean Society of Neurogastroenterology and Motility
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548122/ https://www.ncbi.nlm.nih.gov/pubmed/23350044 http://dx.doi.org/10.5056/jnm.2013.19.1.25 |