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Arsenic Reduction in Drinking Water and Improvement in Skin Lesions: A Follow-Up Study in Bangladesh
Background: Chronic exposure to arsenic is associated with skin lesions. However, it is not known whether reducing arsenic exposure will improve skin lesions. Objective: We evaluated the association between reduced arsenic exposures and skin lesion recovery over time. Methods: A follow-up study of 5...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Institute of Environmental Health Sciences
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548283/ https://www.ncbi.nlm.nih.gov/pubmed/23060367 http://dx.doi.org/10.1289/ehp.1205381 |
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author | Seow, Wei Jie Pan, Wen-Chi Kile, Molly L. Baccarelli, Andrea A. Quamruzzaman, Quazi Rahman, Mahmuder Mahiuddin, Golam Mostofa, Golam Lin, Xihong Christiani, David C. |
author_facet | Seow, Wei Jie Pan, Wen-Chi Kile, Molly L. Baccarelli, Andrea A. Quamruzzaman, Quazi Rahman, Mahmuder Mahiuddin, Golam Mostofa, Golam Lin, Xihong Christiani, David C. |
author_sort | Seow, Wei Jie |
collection | PubMed |
description | Background: Chronic exposure to arsenic is associated with skin lesions. However, it is not known whether reducing arsenic exposure will improve skin lesions. Objective: We evaluated the association between reduced arsenic exposures and skin lesion recovery over time. Methods: A follow-up study of 550 individuals was conducted in 2009–2011 on a baseline population of skin lesion cases (n = 900) previously enrolled in Bangladesh in 2001–2003. Arsenic in drinking water and toenails, and skin lesion status and severity were ascertained at baseline and follow-up. We used logistic regression and generalized estimating equation (GEE) models to evaluate the association between log(10)-transformed arsenic exposure and skin lesion persistence and severity. Results: During the study period, water arsenic concentrations decreased in this population by 41% overall, and 65 individuals who had skin lesions at baseline had no identifiable lesions at follow-up. In the adjusted models, every log(10) decrease in water arsenic and toenail arsenic was associated with 22% [odds ratio (OR) = 1.22; 95% CI: 0.85, 1.78] and 4.5 times (OR = 4.49; 95% CI: 1.94, 11.1) relative increase in skin lesion recovery, respectively. In addition, lower baseline arsenic levels were significantly associated with increased odds of recovery. A log(10) decrease in toenail arsenic from baseline to follow-up was also significantly associated with reduced skin lesion severity in cases over time (mean score change of –5.22 units; 95% CI: –8.61, –1.82). Conclusions: Reducing arsenic exposure increased the odds that an individual with skin lesions would recover or show less severe lesions within 10 years. Reducing arsenic exposure must remain a public health priority in Bangladesh and in other regions affected by arsenic-contaminated water. |
format | Online Article Text |
id | pubmed-3548283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-35482832013-01-30 Arsenic Reduction in Drinking Water and Improvement in Skin Lesions: A Follow-Up Study in Bangladesh Seow, Wei Jie Pan, Wen-Chi Kile, Molly L. Baccarelli, Andrea A. Quamruzzaman, Quazi Rahman, Mahmuder Mahiuddin, Golam Mostofa, Golam Lin, Xihong Christiani, David C. Environ Health Perspect Research Background: Chronic exposure to arsenic is associated with skin lesions. However, it is not known whether reducing arsenic exposure will improve skin lesions. Objective: We evaluated the association between reduced arsenic exposures and skin lesion recovery over time. Methods: A follow-up study of 550 individuals was conducted in 2009–2011 on a baseline population of skin lesion cases (n = 900) previously enrolled in Bangladesh in 2001–2003. Arsenic in drinking water and toenails, and skin lesion status and severity were ascertained at baseline and follow-up. We used logistic regression and generalized estimating equation (GEE) models to evaluate the association between log(10)-transformed arsenic exposure and skin lesion persistence and severity. Results: During the study period, water arsenic concentrations decreased in this population by 41% overall, and 65 individuals who had skin lesions at baseline had no identifiable lesions at follow-up. In the adjusted models, every log(10) decrease in water arsenic and toenail arsenic was associated with 22% [odds ratio (OR) = 1.22; 95% CI: 0.85, 1.78] and 4.5 times (OR = 4.49; 95% CI: 1.94, 11.1) relative increase in skin lesion recovery, respectively. In addition, lower baseline arsenic levels were significantly associated with increased odds of recovery. A log(10) decrease in toenail arsenic from baseline to follow-up was also significantly associated with reduced skin lesion severity in cases over time (mean score change of –5.22 units; 95% CI: –8.61, –1.82). Conclusions: Reducing arsenic exposure increased the odds that an individual with skin lesions would recover or show less severe lesions within 10 years. Reducing arsenic exposure must remain a public health priority in Bangladesh and in other regions affected by arsenic-contaminated water. National Institute of Environmental Health Sciences 2012-10-10 2012-12 /pmc/articles/PMC3548283/ /pubmed/23060367 http://dx.doi.org/10.1289/ehp.1205381 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Research Seow, Wei Jie Pan, Wen-Chi Kile, Molly L. Baccarelli, Andrea A. Quamruzzaman, Quazi Rahman, Mahmuder Mahiuddin, Golam Mostofa, Golam Lin, Xihong Christiani, David C. Arsenic Reduction in Drinking Water and Improvement in Skin Lesions: A Follow-Up Study in Bangladesh |
title | Arsenic Reduction in Drinking Water and Improvement in Skin Lesions: A Follow-Up Study in Bangladesh |
title_full | Arsenic Reduction in Drinking Water and Improvement in Skin Lesions: A Follow-Up Study in Bangladesh |
title_fullStr | Arsenic Reduction in Drinking Water and Improvement in Skin Lesions: A Follow-Up Study in Bangladesh |
title_full_unstemmed | Arsenic Reduction in Drinking Water and Improvement in Skin Lesions: A Follow-Up Study in Bangladesh |
title_short | Arsenic Reduction in Drinking Water and Improvement in Skin Lesions: A Follow-Up Study in Bangladesh |
title_sort | arsenic reduction in drinking water and improvement in skin lesions: a follow-up study in bangladesh |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548283/ https://www.ncbi.nlm.nih.gov/pubmed/23060367 http://dx.doi.org/10.1289/ehp.1205381 |
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