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Effectiveness of malic acid 1% in patients with xerostomia induced by antihypertensive drugs
Objectives: Assessing the clinical effectiveness of a topical sialogogue on spray (malic acid, 1%) in the treatment of xerostomia induced by antihypertensive drugs. Study Design: This research has been carried out through a randomized double-blind clinical trial. 45 patients suffering from hypertens...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medicina Oral S.L.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548619/ https://www.ncbi.nlm.nih.gov/pubmed/22926481 http://dx.doi.org/10.4317/medoral.18206 |
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author | Gómez-Moreno, Gerardo Guardia, Javier Aguilar-Salvatierra, Antonio Cabrera-Ayala, Maribel Maté-Sánchez de-Val, José E. Calvo-Guirado, José L. |
author_facet | Gómez-Moreno, Gerardo Guardia, Javier Aguilar-Salvatierra, Antonio Cabrera-Ayala, Maribel Maté-Sánchez de-Val, José E. Calvo-Guirado, José L. |
author_sort | Gómez-Moreno, Gerardo |
collection | PubMed |
description | Objectives: Assessing the clinical effectiveness of a topical sialogogue on spray (malic acid, 1%) in the treatment of xerostomia induced by antihypertensive drugs. Study Design: This research has been carried out through a randomized double-blind clinical trial. 45 patients suffering from hypertensive drugs-induced xerostomia were divided into 2 groups: the first group (25 patients) received a topical sialogogue on spray (malic acid, 1%) whereas the second group (20 patients) received a placebo. Both of them were administered on demand for 2 weeks. Dry Mouth Questionnaire (DMQ) was used in order to evaluate xerostomia levels before and after product/placebo application. Unstimulated and stimulated salivary flows rates, before and after application, were measured. All the statistical analyses were performed by using SPSS software v17.0. Different DMQ scores at the earliest and final stage of the trial were analysed by using Mann-Whitney U test, whereas Student’s T-test was used to analyse salivary flows. Critical p-value was established at p<0.05. Results: DMQ scores increased significantly (clinical recovery) from 1.21 to 3.36 points (p<0.05) after malic acid (1%) application whereas DMQ scores increased from 1.18 to 1.34 points (p>0.05) after placebo application. After two weeks of treatment with malic acid, unstimulated salivary flow increased from 0.17 to 0.242 mL/min whereas the stimulated one increased from 0.66 to 0.92 mL/min (p<0.05). After placebo application unstimulated flow ranged from 0.152 to 0.146 mL/min and stimulated flow increased from 0.67 to 0.70 mL/min (p>0.05). Conclusions: Malic acid 1% spray improved antihypertensive-induced xerostomia and stimulated the production of saliva. Key words:Xerostomia, hyposialia, malic acid, antihypertensive drugs. |
format | Online Article Text |
id | pubmed-3548619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Medicina Oral S.L. |
record_format | MEDLINE/PubMed |
spelling | pubmed-35486192013-01-23 Effectiveness of malic acid 1% in patients with xerostomia induced by antihypertensive drugs Gómez-Moreno, Gerardo Guardia, Javier Aguilar-Salvatierra, Antonio Cabrera-Ayala, Maribel Maté-Sánchez de-Val, José E. Calvo-Guirado, José L. Med Oral Patol Oral Cir Bucal Research-Article Objectives: Assessing the clinical effectiveness of a topical sialogogue on spray (malic acid, 1%) in the treatment of xerostomia induced by antihypertensive drugs. Study Design: This research has been carried out through a randomized double-blind clinical trial. 45 patients suffering from hypertensive drugs-induced xerostomia were divided into 2 groups: the first group (25 patients) received a topical sialogogue on spray (malic acid, 1%) whereas the second group (20 patients) received a placebo. Both of them were administered on demand for 2 weeks. Dry Mouth Questionnaire (DMQ) was used in order to evaluate xerostomia levels before and after product/placebo application. Unstimulated and stimulated salivary flows rates, before and after application, were measured. All the statistical analyses were performed by using SPSS software v17.0. Different DMQ scores at the earliest and final stage of the trial were analysed by using Mann-Whitney U test, whereas Student’s T-test was used to analyse salivary flows. Critical p-value was established at p<0.05. Results: DMQ scores increased significantly (clinical recovery) from 1.21 to 3.36 points (p<0.05) after malic acid (1%) application whereas DMQ scores increased from 1.18 to 1.34 points (p>0.05) after placebo application. After two weeks of treatment with malic acid, unstimulated salivary flow increased from 0.17 to 0.242 mL/min whereas the stimulated one increased from 0.66 to 0.92 mL/min (p<0.05). After placebo application unstimulated flow ranged from 0.152 to 0.146 mL/min and stimulated flow increased from 0.67 to 0.70 mL/min (p>0.05). Conclusions: Malic acid 1% spray improved antihypertensive-induced xerostomia and stimulated the production of saliva. Key words:Xerostomia, hyposialia, malic acid, antihypertensive drugs. Medicina Oral S.L. 2013-01 2012-08-28 /pmc/articles/PMC3548619/ /pubmed/22926481 http://dx.doi.org/10.4317/medoral.18206 Text en Copyright: © 2013 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research-Article Gómez-Moreno, Gerardo Guardia, Javier Aguilar-Salvatierra, Antonio Cabrera-Ayala, Maribel Maté-Sánchez de-Val, José E. Calvo-Guirado, José L. Effectiveness of malic acid 1% in patients with xerostomia induced by antihypertensive drugs |
title | Effectiveness of malic acid 1% in patients with
xerostomia induced by antihypertensive drugs |
title_full | Effectiveness of malic acid 1% in patients with
xerostomia induced by antihypertensive drugs |
title_fullStr | Effectiveness of malic acid 1% in patients with
xerostomia induced by antihypertensive drugs |
title_full_unstemmed | Effectiveness of malic acid 1% in patients with
xerostomia induced by antihypertensive drugs |
title_short | Effectiveness of malic acid 1% in patients with
xerostomia induced by antihypertensive drugs |
title_sort | effectiveness of malic acid 1% in patients with
xerostomia induced by antihypertensive drugs |
topic | Research-Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548619/ https://www.ncbi.nlm.nih.gov/pubmed/22926481 http://dx.doi.org/10.4317/medoral.18206 |
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