Expression of transforming growth factor β and its correlation with lipodystrophy in oral submucous fibrosis: An immunohistochemical study

Objective: In our routine review of Oral Submucous Fibrosis (OSMF) biopsies, we observed decreased adipose tissue even though most are from buccal mucosa. Pathogenesis of OSMF has demonstrated the role of Transforming Growth Factor β (TGF β), in causing fibrosis. This study aims to correlate the rol...

Descripción completa

Detalles Bibliográficos
Autores principales: Kale, Alka D., Mane, Deepa R., Shukla, Deepika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2013
Materias:
Research-Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548630/
https://www.ncbi.nlm.nih.gov/pubmed/22926483
http://dx.doi.org/10.4317/medoral.18226
_version_ 1782256335919775744
author Kale, Alka D.
Mane, Deepa R.
Shukla, Deepika
author_facet Kale, Alka D.
Mane, Deepa R.
Shukla, Deepika
author_sort Kale, Alka D.
collection PubMed
description Objective: In our routine review of Oral Submucous Fibrosis (OSMF) biopsies, we observed decreased adipose tissue even though most are from buccal mucosa. Pathogenesis of OSMF has demonstrated the role of Transforming Growth Factor β (TGF β), in causing fibrosis. This study aims to correlate the role of TGF β with loss of adipose tissue in OSMF. Study Design: From our archives, 84 OSMF cases (24 early and 60 advanced OSMF) were screened for adipose tissue. Immunoexpression of TGF β in these cases were investigated. Results: Adipose tissue was seen in 67% of early OSMF and in 13% of advanced cases. Early cases showed more intense TGF β staining of epithelium, fibroblast, macrophages and inflammatory cells than the advanced cases. Conclusion: These findings suggest that TGF β plays a key role in causing lipodystrophy in OSMF and is secreted more during early course of the disease than in advanced stage. Key words:Adipose tissue, oral submucous fibrosis (OSMF), transforming growth factor β (TGF β), lipodystrophy.
format Online
Article
Text
id pubmed-3548630
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Medicina Oral S.L.
record_format MEDLINE/PubMed
spelling pubmed-35486302013-01-23 Expression of transforming growth factor β and its correlation with lipodystrophy in oral submucous fibrosis: An immunohistochemical study Kale, Alka D. Mane, Deepa R. Shukla, Deepika Med Oral Patol Oral Cir Bucal Research-Article Objective: In our routine review of Oral Submucous Fibrosis (OSMF) biopsies, we observed decreased adipose tissue even though most are from buccal mucosa. Pathogenesis of OSMF has demonstrated the role of Transforming Growth Factor β (TGF β), in causing fibrosis. This study aims to correlate the role of TGF β with loss of adipose tissue in OSMF. Study Design: From our archives, 84 OSMF cases (24 early and 60 advanced OSMF) were screened for adipose tissue. Immunoexpression of TGF β in these cases were investigated. Results: Adipose tissue was seen in 67% of early OSMF and in 13% of advanced cases. Early cases showed more intense TGF β staining of epithelium, fibroblast, macrophages and inflammatory cells than the advanced cases. Conclusion: These findings suggest that TGF β plays a key role in causing lipodystrophy in OSMF and is secreted more during early course of the disease than in advanced stage. Key words:Adipose tissue, oral submucous fibrosis (OSMF), transforming growth factor β (TGF β), lipodystrophy. Medicina Oral S.L. 2013-01 2012-08-28 /pmc/articles/PMC3548630/ /pubmed/22926483 http://dx.doi.org/10.4317/medoral.18226 Text en Copyright: © 2013 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research-Article
Kale, Alka D.
Mane, Deepa R.
Shukla, Deepika
Expression of transforming growth factor β and its correlation with lipodystrophy in oral submucous fibrosis: An immunohistochemical study
title Expression of transforming growth factor β and its correlation with lipodystrophy in oral submucous fibrosis: An immunohistochemical study
title_full Expression of transforming growth factor β and its correlation with lipodystrophy in oral submucous fibrosis: An immunohistochemical study
title_fullStr Expression of transforming growth factor β and its correlation with lipodystrophy in oral submucous fibrosis: An immunohistochemical study
title_full_unstemmed Expression of transforming growth factor β and its correlation with lipodystrophy in oral submucous fibrosis: An immunohistochemical study
title_short Expression of transforming growth factor β and its correlation with lipodystrophy in oral submucous fibrosis: An immunohistochemical study
title_sort expression of transforming growth factor β and its correlation with lipodystrophy in oral submucous fibrosis: an immunohistochemical study
topic Research-Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548630/
https://www.ncbi.nlm.nih.gov/pubmed/22926483
http://dx.doi.org/10.4317/medoral.18226
work_keys_str_mv AT kalealkad expressionoftransforminggrowthfactorbanditscorrelationwithlipodystrophyinoralsubmucousfibrosisanimmunohistochemicalstudy
AT manedeepar expressionoftransforminggrowthfactorbanditscorrelationwithlipodystrophyinoralsubmucousfibrosisanimmunohistochemicalstudy
AT shukladeepika expressionoftransforminggrowthfactorbanditscorrelationwithlipodystrophyinoralsubmucousfibrosisanimmunohistochemicalstudy

Ejemplares similares