Cargando…

RNA-Seq for Enrichment and Analysis of IRF5 Transcript Expression in SLE

Polymorphisms in the interferon regulatory factor 5 (IRF5) gene have been consistently replicated and shown to confer risk for or protection from the development of systemic lupus erythematosus (SLE). IRF5 expression is significantly upregulated in SLE patients and upregulation associates with IRF5-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stone, Rivka C., Du, Peicheng, Feng, Di, Dhawan, Kopal, Rönnblom, Lars, Eloranta, Maija-Leena, Donnelly, Robert, Barnes, Betsy J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548774/ https://www.ncbi.nlm.nih.gov/pubmed/23349905 http://dx.doi.org/10.1371/journal.pone.0054487

Ejemplares similares

Cause and consequences of the activated type I interferon system in SLE
por: Eloranta, Maija-Leena, et al.
Publicado: (2016)

Plasmacytoid dendritic cells and RNA-containing immune complexes drive expansion of peripheral B cell subsets with an SLE-like phenotype
por: Berggren, Olof, et al.
Publicado: (2017)

The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE
por: Hagberg, Niklas, et al.
Publicado: (2018)

IRF5 expression profiling in SLE patients: new leads to a pathogenic signature?
por: Barnes, BJ, et al.
Publicado: (2012)

Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations
por: Wang, Chuan, et al.
Publicado: (2013)

NETs decorated with bioactive IL-33 infiltrate inflamed tissues and induce IFN-α production in patients with SLE
por: Georgakis, Spiros, et al.
Publicado: (2021)

The regulation and pharmacological modulation of immune complex induced type III IFN production by plasmacytoid dendritic cells
por: Hjorton, Karin, et al.
Publicado: (2020)

Interferon pathway in SLE: one key to unlocking the mystery of the disease
por: Rönnblom, Lars, et al.
Publicado: (2019)

Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease
por: Yavuz, Sule, et al.
Publicado: (2022)

Allele-specific transcription factor binding to common and rare variants associated with disease and gene expression
por: Cavalli, Marco, et al.
Publicado: (2016)

C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205
por: Enocsson, Helena, et al.
Publicado: (2021)

Comparison of Surrogate Markers of the Type I Interferon Response and Their Ability to Mirror Disease Activity in Systemic Lupus Erythematosus
por: Enocsson, Helena, et al.
Publicado: (2021)

Targeting IRF5 inhibition in human B cells: identification of new functional roles that implicate IRF5 in systemic lupus erythematosus B-cell pathology
por: De, Saurav, et al.
Publicado: (2014)

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE
por: Sandling, Johanna K, et al.
Publicado: (2011)

Interferon-α enhances the IL-12-induced STAT4 activation selectively in carriers of the STAT4 SLE risk allele rs7574865[T]
por: Hagberg, Niklas, et al.
Publicado: (2019)

Therapeutic Targeting of IRFs: Pathway-Dependence or Structure-Based?
por: Thompson, Cherrie D., et al.
Publicado: (2018)

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5
por: Sigurdsson, Snaevar, et al.
Publicado: (2008)

Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor
por: Hjorton, Karin, et al.
Publicado: (2018)

A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts
por: Farias, Fabiana H. G., et al.
Publicado: (2018)

IRF5 is elevated in childhood-onset SLE and regulated by histone acetyltransferase and histone deacetylase inhibitors
por: Shu, Jin, et al.
Publicado: (2017)

B Cell-Intrinsic Role for IRF5 in TLR9/BCR-Induced Human B Cell Activation, Proliferation, and Plasmablast Differentiation
por: De, Saurav, et al.
Publicado: (2018)

Measurement of hydroxychloroquine in blood from SLE patients using LC-HRMS—evaluation of whole blood, plasma, and serum as sample matrices
por: Carlsson, Henrik, et al.
Publicado: (2020)

DNA Methylation-Based Interferon Scores Associate With Sub-Phenotypes in Primary Sjögren’s Syndrome
por: Imgenberg-Kreuz, Juliana, et al.
Publicado: (2021)

IRF1 Downregulation by Ras/MEK Is Independent of Translational Control of IRF1 mRNA
por: Komatsu, Yumiko, et al.
Publicado: (2016)

Potential T Cell-Intrinsic Regulatory Roles for IRF5 via Cytokine Modulation in T Helper Subset Differentiation and Function
por: Brune, Zarina, et al.
Publicado: (2020)

Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis
por: Bolin, Karin, et al.
Publicado: (2013)

Genome-wide DNA methylation analysis in multiple tissues in primary Sjögren's syndrome reveals regulatory effects at interferon-induced genes
por: Imgenberg-Kreuz, Juliana, et al.
Publicado: (2016)

Function of multiple sclerosis-protective HLA class I alleles revealed by genome-wide protein-quantitative trait loci mapping of interferon signalling
por: Lundtoft, Christian, et al.
Publicado: (2020)

Specific detection of interferon regulatory factor 5 (IRF5): A case of antibody inequality
por: Li, Dan, et al.
Publicado: (2016)

Shared and Distinct Functions of the Transcription Factors IRF4 and IRF8 in Myeloid Cell Development
por: Yamamoto, Michio, et al.
Publicado: (2011)

IRF4 as an Oncogenic Master Transcription Factor
por: Wong, Regina Wan Ju, et al.
Publicado: (2022)

Transcriptional reprogramming by mutated IRF4 in lymphoma
por: Schleussner, Nikolai, et al.
Publicado: (2023)

Detection of neutrophil extracellular traps in patient plasma: method development and validation in systemic lupus erythematosus and healthy donors that carry IRF5 genetic risk
por: Matta, Bharati, et al.
Publicado: (2022)

Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus
por: Almlöf, Jonas Carlsson, et al.
Publicado: (2019)

HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections
por: Sun, Lei, et al.
Publicado: (2017)

Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4
por: Campos Carrascosa, Lucia, et al.
Publicado: (2017)

Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus
por: Jönsen, Andreas, et al.
Publicado: (2011)

Recruitment and Activation of Natural Killer (Nk) Cells in Vivo Determined by the Target Cell Phenotype: An Adaptive Component of Nk Cell–Mediated Responses
por: Glas, Rickard, et al.
Publicado: (2000)

Trans-Ethnic Mapping of BANK1 Identifies Two Independent SLE-Risk Linkage Groups Enriched for Co-Transcriptional Splicing Marks
por: Martínez-Bueno, Manuel, et al.
Publicado: (2018)

Contributions of de novo variants to systemic lupus erythematosus
por: Almlöf, Jonas Carlsson, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vn7f8n9j93rh85sr25tqr1uoc9