Cargando…
Mutations in the Hedgehog Pathway Genes SMO and PTCH1 in Human Gastric Tumors
The causal role of the hedgehog pathway in cancer has been best documented in basal cell carcinoma of the skin. To assess potential DNA alterations of the hedgehog pathway in gastric cancer, we sequenced SMO and PTCH1 genes in a set of 39 gastric tumors. Tumors were classified by histology based on...
Autores principales: | Wang, Xi-De, Inzunza, Hector, Chang, Han, Qi, Zhenhao, Hu, Beihong, Malone, Daniel, Cogswell, John |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548780/ https://www.ncbi.nlm.nih.gov/pubmed/23349881 http://dx.doi.org/10.1371/journal.pone.0054415 |
Ejemplares similares
-
Different Response of Ptch Mutant and Ptch Wildtype Rhabdomyosarcoma Toward SMO and PI3K Inhibitors
por: Geyer, Natalie, et al.
Publicado: (2018) -
A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth
por: Lospinoso Severini, Ludovica, et al.
Publicado: (2019) -
Patched Homolog 1 (PTCH1) Mutation in a CIC-Rearranged Sarcoma: Lack of Response to the Smoothened (SMO) Vismodegib
por: Wu, David J, et al.
Publicado: (2023) -
Structural basis of sterol recognition by human hedgehog receptor PTCH1
por: Qi, Chao, et al.
Publicado: (2019) -
PTCH1, a receptor of Hedgehog signaling pathway, is correlated with metastatic potential of colorectal cancer
por: You, Sihong, et al.
Publicado: (2010)