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Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy

Targeted radiotherapies maximize cytotoxicty to cancer cells. In vivo α-generator targeted radiotherapies can deliver multiple α particles to a receptor site dramatically amplifying the radiation dose delivered to the target. The major challenge with α-generator radiotherapies is that traditional ch...

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Autores principales: McLaughlin, Mark F., Woodward, Jonathan, Boll, Rose A., Wall, Jonathan S., Rondinone, Adam J., Kennel, Stephen J., Mirzadeh, Saed, Robertson, J. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548790/
https://www.ncbi.nlm.nih.gov/pubmed/23349921
http://dx.doi.org/10.1371/journal.pone.0054531
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author McLaughlin, Mark F.
Woodward, Jonathan
Boll, Rose A.
Wall, Jonathan S.
Rondinone, Adam J.
Kennel, Stephen J.
Mirzadeh, Saed
Robertson, J. David
author_facet McLaughlin, Mark F.
Woodward, Jonathan
Boll, Rose A.
Wall, Jonathan S.
Rondinone, Adam J.
Kennel, Stephen J.
Mirzadeh, Saed
Robertson, J. David
author_sort McLaughlin, Mark F.
collection PubMed
description Targeted radiotherapies maximize cytotoxicty to cancer cells. In vivo α-generator targeted radiotherapies can deliver multiple α particles to a receptor site dramatically amplifying the radiation dose delivered to the target. The major challenge with α-generator radiotherapies is that traditional chelating moieties are unable to sequester the radioactive daughters in the bioconjugate which is critical to minimize toxicity to healthy, non-target tissue. The recoil energy of the (225)Ac daughters following α decay will sever any metal-ligand bond used to form the bioconjugate. This work demonstrates that an engineered multilayered nanoparticle-antibody conjugate can deliver multiple α radiations and contain the decay daughters of (225)Ac while targeting biologically relevant receptors in a female BALB/c mouse model. These multi-shell nanoparticles combine the radiation resistance of lanthanide phosphate to contain (225)Ac and its radioactive decay daughters, the magnetic properties of gadolinium phosphate for easy separation, and established gold chemistry for attachment of targeting moieties.
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spelling pubmed-35487902013-01-24 Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy McLaughlin, Mark F. Woodward, Jonathan Boll, Rose A. Wall, Jonathan S. Rondinone, Adam J. Kennel, Stephen J. Mirzadeh, Saed Robertson, J. David PLoS One Research Article Targeted radiotherapies maximize cytotoxicty to cancer cells. In vivo α-generator targeted radiotherapies can deliver multiple α particles to a receptor site dramatically amplifying the radiation dose delivered to the target. The major challenge with α-generator radiotherapies is that traditional chelating moieties are unable to sequester the radioactive daughters in the bioconjugate which is critical to minimize toxicity to healthy, non-target tissue. The recoil energy of the (225)Ac daughters following α decay will sever any metal-ligand bond used to form the bioconjugate. This work demonstrates that an engineered multilayered nanoparticle-antibody conjugate can deliver multiple α radiations and contain the decay daughters of (225)Ac while targeting biologically relevant receptors in a female BALB/c mouse model. These multi-shell nanoparticles combine the radiation resistance of lanthanide phosphate to contain (225)Ac and its radioactive decay daughters, the magnetic properties of gadolinium phosphate for easy separation, and established gold chemistry for attachment of targeting moieties. Public Library of Science 2013-01-18 /pmc/articles/PMC3548790/ /pubmed/23349921 http://dx.doi.org/10.1371/journal.pone.0054531 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
McLaughlin, Mark F.
Woodward, Jonathan
Boll, Rose A.
Wall, Jonathan S.
Rondinone, Adam J.
Kennel, Stephen J.
Mirzadeh, Saed
Robertson, J. David
Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy
title Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy
title_full Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy
title_fullStr Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy
title_full_unstemmed Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy
title_short Gold Coated Lanthanide Phosphate Nanoparticles for Targeted Alpha Generator Radiotherapy
title_sort gold coated lanthanide phosphate nanoparticles for targeted alpha generator radiotherapy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548790/
https://www.ncbi.nlm.nih.gov/pubmed/23349921
http://dx.doi.org/10.1371/journal.pone.0054531
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