Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are relentlessly progressive neurodegenerative disorders with overlapping clinical, genetic and pathological features. Cytoplasmic inclusions of fused in sarcoma (FUS) are the hallmark of several forms of FTLD and ALS p...

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Detalles Bibliográficos
Autores principales: Mitchell, Jacqueline C., McGoldrick, Philip, Vance, Caroline, Hortobagyi, Tibor, Sreedharan, Jemeen, Rogelj, Boris, Tudor, Elizabeth L., Smith, Bradley N., Klasen, Christian, Miller, Christopher C. J., Cooper, Jonathan D., Greensmith, Linda, Shaw, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549237/
https://www.ncbi.nlm.nih.gov/pubmed/22961620
http://dx.doi.org/10.1007/s00401-012-1043-z

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