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mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging

BACKGROUND: The mammalian target of rapamycin (mTOR) signalling pathway has a key role in cellular regulation and several diseases. While it is thought that Rheb GTPase regulates mTOR, acting immediately upstream, while raptor is immediately downstream of mTOR, direct interactions have yet to be ver...

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Detalles Bibliográficos
Autores principales:	Yadav, Rahul B, Burgos, Pierre, Parker, Anthony W, Iadevaia, Valentina, Proud, Christopher G, Allen, Rodger A, O'Connell, James P, Jeshtadi, Ananya, Stubbs, Christopher D, Botchway, Stanley W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549280/ https://www.ncbi.nlm.nih.gov/pubmed/23311891 http://dx.doi.org/10.1186/1471-2121-14-3

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