t(17;19) in Children with Acute Lymphocytic Leukemia: A Report of 3 Cases and a Review of the Literature

Several cytogenetic abnormalities identified in patients with childhood acute lymphocytic leukemia (ALL) have been associated with a poor prognosis. There are several case reports in the literature describing t(17;19) in children with ALL. This translocation has been associated with hypercalcemia, c...

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Autores principales: Minson, Katherine A., Prasad, Pinki, Vear, Susan, Borinstein, Scott, Ho, Richard, Domm, Jennifer, Frangoul, Haydar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549381/
https://www.ncbi.nlm.nih.gov/pubmed/23346431
http://dx.doi.org/10.1155/2013/563291
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author Minson, Katherine A.
Prasad, Pinki
Vear, Susan
Borinstein, Scott
Ho, Richard
Domm, Jennifer
Frangoul, Haydar
author_facet Minson, Katherine A.
Prasad, Pinki
Vear, Susan
Borinstein, Scott
Ho, Richard
Domm, Jennifer
Frangoul, Haydar
author_sort Minson, Katherine A.
collection PubMed
description Several cytogenetic abnormalities identified in patients with childhood acute lymphocytic leukemia (ALL) have been associated with a poor prognosis. There are several case reports in the literature describing t(17;19) in children with ALL. This translocation has been associated with hypercalcemia, coagulopathy, and poor outcome. We present three cases of ALL with t(17;19) treated at our institution and review the outcome of children reported in the medical literature.
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spelling pubmed-35493812013-01-23 t(17;19) in Children with Acute Lymphocytic Leukemia: A Report of 3 Cases and a Review of the Literature Minson, Katherine A. Prasad, Pinki Vear, Susan Borinstein, Scott Ho, Richard Domm, Jennifer Frangoul, Haydar Case Rep Hematol Case Report Several cytogenetic abnormalities identified in patients with childhood acute lymphocytic leukemia (ALL) have been associated with a poor prognosis. There are several case reports in the literature describing t(17;19) in children with ALL. This translocation has been associated with hypercalcemia, coagulopathy, and poor outcome. We present three cases of ALL with t(17;19) treated at our institution and review the outcome of children reported in the medical literature. Hindawi Publishing Corporation 2013 2013-01-03 /pmc/articles/PMC3549381/ /pubmed/23346431 http://dx.doi.org/10.1155/2013/563291 Text en Copyright © 2013 Katherine A. Minson et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Minson, Katherine A.
Prasad, Pinki
Vear, Susan
Borinstein, Scott
Ho, Richard
Domm, Jennifer
Frangoul, Haydar
t(17;19) in Children with Acute Lymphocytic Leukemia: A Report of 3 Cases and a Review of the Literature
title t(17;19) in Children with Acute Lymphocytic Leukemia: A Report of 3 Cases and a Review of the Literature
title_full t(17;19) in Children with Acute Lymphocytic Leukemia: A Report of 3 Cases and a Review of the Literature
title_fullStr t(17;19) in Children with Acute Lymphocytic Leukemia: A Report of 3 Cases and a Review of the Literature
title_full_unstemmed t(17;19) in Children with Acute Lymphocytic Leukemia: A Report of 3 Cases and a Review of the Literature
title_short t(17;19) in Children with Acute Lymphocytic Leukemia: A Report of 3 Cases and a Review of the Literature
title_sort t(17;19) in children with acute lymphocytic leukemia: a report of 3 cases and a review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549381/
https://www.ncbi.nlm.nih.gov/pubmed/23346431
http://dx.doi.org/10.1155/2013/563291
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