Carbocyclic Analogues of Inosine-5’-Monophosphate: Synthesis and Biological Activity

9-(4’-Phosphonomethoxy-2’-cyclopenten-1’-yl)hypoxanthine and 9-(4’-phosphonomethoxy-2’,3’-dihydroxycyclopenten-1’-yl)hypoxanthine were synthesized as isosteric carbocyclic analogues of inosine-5’-monophosphate. The synthesized compounds were shown to be capable of inhibiting the activity of human ty...

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Autores principales: Matyugina, E.S., Andreevskaya, S.N., Smirnova, T.G., Khandazhinskaya, A.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549521/
https://www.ncbi.nlm.nih.gov/pubmed/23346382
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author Matyugina, E.S.
Andreevskaya, S.N.
Smirnova, T.G.
Khandazhinskaya, A.L.
author_facet Matyugina, E.S.
Andreevskaya, S.N.
Smirnova, T.G.
Khandazhinskaya, A.L.
author_sort Matyugina, E.S.
collection PubMed
description 9-(4’-Phosphonomethoxy-2’-cyclopenten-1’-yl)hypoxanthine and 9-(4’-phosphonomethoxy-2’,3’-dihydroxycyclopenten-1’-yl)hypoxanthine were synthesized as isosteric carbocyclic analogues of inosine-5’-monophosphate. The synthesized compounds were shown to be capable of inhibiting the activity of human type II inosine-5′-monophosphate dehydrogenase (IMPDH II) (IC(50 )= 500 µM) and to have no significant effects on the growth ofMycobacterium tuberculosis.
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spelling pubmed-35495212013-01-23 Carbocyclic Analogues of Inosine-5’-Monophosphate: Synthesis and Biological Activity Matyugina, E.S. Andreevskaya, S.N. Smirnova, T.G. Khandazhinskaya, A.L. Acta Naturae Research Article 9-(4’-Phosphonomethoxy-2’-cyclopenten-1’-yl)hypoxanthine and 9-(4’-phosphonomethoxy-2’,3’-dihydroxycyclopenten-1’-yl)hypoxanthine were synthesized as isosteric carbocyclic analogues of inosine-5’-monophosphate. The synthesized compounds were shown to be capable of inhibiting the activity of human type II inosine-5′-monophosphate dehydrogenase (IMPDH II) (IC(50 )= 500 µM) and to have no significant effects on the growth ofMycobacterium tuberculosis. A.I. Gordeyev 2012 /pmc/articles/PMC3549521/ /pubmed/23346382 Text en Copyright © 2012 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Matyugina, E.S.
Andreevskaya, S.N.
Smirnova, T.G.
Khandazhinskaya, A.L.
Carbocyclic Analogues of Inosine-5’-Monophosphate: Synthesis and Biological Activity
title Carbocyclic Analogues of Inosine-5’-Monophosphate: Synthesis and Biological Activity
title_full Carbocyclic Analogues of Inosine-5’-Monophosphate: Synthesis and Biological Activity
title_fullStr Carbocyclic Analogues of Inosine-5’-Monophosphate: Synthesis and Biological Activity
title_full_unstemmed Carbocyclic Analogues of Inosine-5’-Monophosphate: Synthesis and Biological Activity
title_short Carbocyclic Analogues of Inosine-5’-Monophosphate: Synthesis and Biological Activity
title_sort carbocyclic analogues of inosine-5’-monophosphate: synthesis and biological activity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549521/
https://www.ncbi.nlm.nih.gov/pubmed/23346382
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