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NF135.C10: A New Plasmodium falciparum Clone for Controlled Human Malaria Infections
We established a new field clone of Plasmodium falciparum for use in controlled human malaria infections and vaccine studies to complement the current small portfolio of P. falciparum strains, primarily based on NF54. The Cambodian clone NF135.C10 consistently produced gametocytes and generated subs...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549599/ https://www.ncbi.nlm.nih.gov/pubmed/23186785 http://dx.doi.org/10.1093/infdis/jis725 |
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| author | Teirlinck, Anne C. Roestenberg, Meta van de Vegte-Bolmer, Marga Scholzen, Anja Heinrichs, Moniek J. L. Siebelink-Stoter, Rianne Graumans, Wouter van Gemert, Geert-Jan Teelen, Karina Vos, Martijn W. Nganou-Makamdop, Krystelle Borrmann, Steffen Rozier, Yolanda P. A. Erkens, Marianne A. A. Luty, Adrian J. F. Hermsen, Cornelus C. Sim, B. Kim Lee van Lieshout, Lisette Hoffman, Stephen L. Visser, Leo G. Sauerwein, Robert W. |
| author_facet | Teirlinck, Anne C. Roestenberg, Meta van de Vegte-Bolmer, Marga Scholzen, Anja Heinrichs, Moniek J. L. Siebelink-Stoter, Rianne Graumans, Wouter van Gemert, Geert-Jan Teelen, Karina Vos, Martijn W. Nganou-Makamdop, Krystelle Borrmann, Steffen Rozier, Yolanda P. A. Erkens, Marianne A. A. Luty, Adrian J. F. Hermsen, Cornelus C. Sim, B. Kim Lee van Lieshout, Lisette Hoffman, Stephen L. Visser, Leo G. Sauerwein, Robert W. |
| author_sort | Teirlinck, Anne C. |
| collection | PubMed |
| description | We established a new field clone of Plasmodium falciparum for use in controlled human malaria infections and vaccine studies to complement the current small portfolio of P. falciparum strains, primarily based on NF54. The Cambodian clone NF135.C10 consistently produced gametocytes and generated substantial numbers of sporozoites in Anopheles mosquitoes and diverged from NF54 parasites by genetic markers. In a controlled human malaria infection trial, 3 of 5 volunteers challenged by mosquitoes infected with NF135.C10 and 4 of 5 challenged with NF54 developed parasitemia as detected with microscopy. The 2 strains induced similar clinical signs and symptoms as well as cellular immunological responses. Clinical Trials Registration NCT01002833. |
| format | Online Article Text |
| id | pubmed-3549599 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2013 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-35495992013-01-23 NF135.C10: A New Plasmodium falciparum Clone for Controlled Human Malaria Infections Teirlinck, Anne C. Roestenberg, Meta van de Vegte-Bolmer, Marga Scholzen, Anja Heinrichs, Moniek J. L. Siebelink-Stoter, Rianne Graumans, Wouter van Gemert, Geert-Jan Teelen, Karina Vos, Martijn W. Nganou-Makamdop, Krystelle Borrmann, Steffen Rozier, Yolanda P. A. Erkens, Marianne A. A. Luty, Adrian J. F. Hermsen, Cornelus C. Sim, B. Kim Lee van Lieshout, Lisette Hoffman, Stephen L. Visser, Leo G. Sauerwein, Robert W. J Infect Dis Major Articles and Brief Reports We established a new field clone of Plasmodium falciparum for use in controlled human malaria infections and vaccine studies to complement the current small portfolio of P. falciparum strains, primarily based on NF54. The Cambodian clone NF135.C10 consistently produced gametocytes and generated substantial numbers of sporozoites in Anopheles mosquitoes and diverged from NF54 parasites by genetic markers. In a controlled human malaria infection trial, 3 of 5 volunteers challenged by mosquitoes infected with NF135.C10 and 4 of 5 challenged with NF54 developed parasitemia as detected with microscopy. The 2 strains induced similar clinical signs and symptoms as well as cellular immunological responses. Clinical Trials Registration NCT01002833. Oxford University Press 2013-02-15 2012-11-27 /pmc/articles/PMC3549599/ /pubmed/23186785 http://dx.doi.org/10.1093/infdis/jis725 Text en © The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Major Articles and Brief Reports Teirlinck, Anne C. Roestenberg, Meta van de Vegte-Bolmer, Marga Scholzen, Anja Heinrichs, Moniek J. L. Siebelink-Stoter, Rianne Graumans, Wouter van Gemert, Geert-Jan Teelen, Karina Vos, Martijn W. Nganou-Makamdop, Krystelle Borrmann, Steffen Rozier, Yolanda P. A. Erkens, Marianne A. A. Luty, Adrian J. F. Hermsen, Cornelus C. Sim, B. Kim Lee van Lieshout, Lisette Hoffman, Stephen L. Visser, Leo G. Sauerwein, Robert W. NF135.C10: A New Plasmodium falciparum Clone for Controlled Human Malaria Infections |
| title | NF135.C10: A New Plasmodium falciparum Clone for Controlled Human Malaria Infections |
| title_full | NF135.C10: A New Plasmodium falciparum Clone for Controlled Human Malaria Infections |
| title_fullStr | NF135.C10: A New Plasmodium falciparum Clone for Controlled Human Malaria Infections |
| title_full_unstemmed | NF135.C10: A New Plasmodium falciparum Clone for Controlled Human Malaria Infections |
| title_short | NF135.C10: A New Plasmodium falciparum Clone for Controlled Human Malaria Infections |
| title_sort | nf135.c10: a new plasmodium falciparum clone for controlled human malaria infections |
| topic | Major Articles and Brief Reports |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549599/ https://www.ncbi.nlm.nih.gov/pubmed/23186785 http://dx.doi.org/10.1093/infdis/jis725 |
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