Peptide-Conjugation Induced Conformational Changes in Human IgG1 Observed by Optimized Negative-Staining and Individual-Particle Electron Tomography

Peptides show much promise as potent and selective drug candidates. Fusing peptides to a scaffold monoclonal antibody produces a conjugated antibody which has the advantages of peptide activity yet also has the pharmacokinetics determined by the scaffold antibody. However, the conjugated antibody of...

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Detalles Bibliográficos
Autores principales: Tong, Huimin, Zhang, Lei, Kaspar, Allan, Rames, Matthew J., Huang, Liqing, Woodnutt, Gary, Ren, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549606/
https://www.ncbi.nlm.nih.gov/pubmed/23346347
http://dx.doi.org/10.1038/srep01089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549606/
https://www.ncbi.nlm.nih.gov/pubmed/23346347
http://dx.doi.org/10.1038/srep01089

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