Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling

Previous studies have identified Notch as a key regulator of hematopoietic stem cell (HSC) development, but the underlying downstream mechanisms remain unknown. The Notch target Hes1 is widely expressed in the aortic endothelium and hematopoietic clusters, though Hes1-deficient mice show no overt he...

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Detalles Bibliográficos
Autores principales: Guiu, Jordi, Shimizu, Ritsuko, D’Altri, Teresa, Fraser, Stuart T., Hatakeyama, Jun, Bresnick, Emery H., Kageyama, Ryoichiro, Dzierzak, Elaine, Yamamoto, Masayuki, Espinosa, Lluis, Bigas, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549704/
https://www.ncbi.nlm.nih.gov/pubmed/23267012
http://dx.doi.org/10.1084/jem.20120993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549704/
https://www.ncbi.nlm.nih.gov/pubmed/23267012
http://dx.doi.org/10.1084/jem.20120993

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