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Conjunctival mass as an initial presentation of mantle cell lymphoma: a case report

BACKGROUND: To describe a rare manifestation of mantle cell lymphoma (MCL) in conjunctiva, with clinical, hisologic, immunohistologic and genetic findings together with review of the Literature. CASE PRESENTATION: Most ocular adnexal lymphomas are extranodal marginal zone B-cell lymphomas of mucosa-...

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Autores principales: Khanlari, Mahsa, Bagheri, Babak, Vojdani, Reza, Mohammadianpanah, Mohammad, Paydar, Shahram, Daneshbod, Yahya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549763/
https://www.ncbi.nlm.nih.gov/pubmed/23210924
http://dx.doi.org/10.1186/1756-0500-5-671
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author Khanlari, Mahsa
Bagheri, Babak
Vojdani, Reza
Mohammadianpanah, Mohammad
Paydar, Shahram
Daneshbod, Yahya
author_facet Khanlari, Mahsa
Bagheri, Babak
Vojdani, Reza
Mohammadianpanah, Mohammad
Paydar, Shahram
Daneshbod, Yahya
author_sort Khanlari, Mahsa
collection PubMed
description BACKGROUND: To describe a rare manifestation of mantle cell lymphoma (MCL) in conjunctiva, with clinical, hisologic, immunohistologic and genetic findings together with review of the Literature. CASE PRESENTATION: Most ocular adnexal lymphomas are extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT). A few cases of ocular adnexal mantle cell lymphomas have been reported in the literature. We present a case of mantle cell lymphoma presenting as right conjunctival mass of at least three months duration in a 64-year-old man. Histopathologic examination showed a proliferation of monomorphous small-to-medium-sized lymphoid cells with cleaved nuclei in the subconjunctiva. By immunohistochemistry, the infiltrate was positive for CD20, CD5, BCL-2, cyclin D1, and the transcription factor SOX11. Fluorescent in situ hybridization demonstrated the presence of IGH-CCND1 fusion indicating t(11;14). CONCLUSION: A rigorous approach to initial diagnosis and staging of small cell lymphomas of the ocular adnexa is needed. The recognition of ocular MCL requires appropriate immunohistochemical staining and/or genetic confirmation to differentiate this rare form of presentation of MCL from other more frequent small cell lymphomas.
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spelling pubmed-35497632013-01-23 Conjunctival mass as an initial presentation of mantle cell lymphoma: a case report Khanlari, Mahsa Bagheri, Babak Vojdani, Reza Mohammadianpanah, Mohammad Paydar, Shahram Daneshbod, Yahya BMC Res Notes Case Report BACKGROUND: To describe a rare manifestation of mantle cell lymphoma (MCL) in conjunctiva, with clinical, hisologic, immunohistologic and genetic findings together with review of the Literature. CASE PRESENTATION: Most ocular adnexal lymphomas are extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT). A few cases of ocular adnexal mantle cell lymphomas have been reported in the literature. We present a case of mantle cell lymphoma presenting as right conjunctival mass of at least three months duration in a 64-year-old man. Histopathologic examination showed a proliferation of monomorphous small-to-medium-sized lymphoid cells with cleaved nuclei in the subconjunctiva. By immunohistochemistry, the infiltrate was positive for CD20, CD5, BCL-2, cyclin D1, and the transcription factor SOX11. Fluorescent in situ hybridization demonstrated the presence of IGH-CCND1 fusion indicating t(11;14). CONCLUSION: A rigorous approach to initial diagnosis and staging of small cell lymphomas of the ocular adnexa is needed. The recognition of ocular MCL requires appropriate immunohistochemical staining and/or genetic confirmation to differentiate this rare form of presentation of MCL from other more frequent small cell lymphomas. BioMed Central 2012-12-04 /pmc/articles/PMC3549763/ /pubmed/23210924 http://dx.doi.org/10.1186/1756-0500-5-671 Text en Copyright ©2012 Khanlari et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Khanlari, Mahsa
Bagheri, Babak
Vojdani, Reza
Mohammadianpanah, Mohammad
Paydar, Shahram
Daneshbod, Yahya
Conjunctival mass as an initial presentation of mantle cell lymphoma: a case report
title Conjunctival mass as an initial presentation of mantle cell lymphoma: a case report
title_full Conjunctival mass as an initial presentation of mantle cell lymphoma: a case report
title_fullStr Conjunctival mass as an initial presentation of mantle cell lymphoma: a case report
title_full_unstemmed Conjunctival mass as an initial presentation of mantle cell lymphoma: a case report
title_short Conjunctival mass as an initial presentation of mantle cell lymphoma: a case report
title_sort conjunctival mass as an initial presentation of mantle cell lymphoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549763/
https://www.ncbi.nlm.nih.gov/pubmed/23210924
http://dx.doi.org/10.1186/1756-0500-5-671
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