Cargando…

EGFR mutations are associated with favorable intracranial response and progression-free survival following brain irradiation in non-small cell lung cancer patients with brain metastases

BACKGROUND: The presence of epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) is associated with increased radiosensitivity in vitro. However, the results from clinical studies regarding the radiosensitivity in NSCLC with mutant EGFR are inconclusive. We retrosp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Hsin-Lun, Chung, Tao-Sang, Ting, Lai-Lei, Tsai, Jo-Ting, Chen, Shang-Wen, Chiou, Jeng-Fong, Leung, Henry Wing-Cheung, Liu, H Eugene
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3549835/ https://www.ncbi.nlm.nih.gov/pubmed/23110940 http://dx.doi.org/10.1186/1748-717X-7-181

Ejemplares similares

Primary treatment of painful bone metastases using magnetic resonance guided focused ultrasound – initial clinical experience in Taiwan
por: Lee, Hsin-Lun, et al.
Publicado: (2015)

Favorable prognosis of breast cancer brain metastases patients with limited intracranial and extracranial metastatic lesions
por: Shi, Wei, et al.
Publicado: (2023)

Dose escalation of osimertinib for intracranial progression in EGFR mutated non-small-cell lung cancer with brain metastases
por: Goldstein, Iris M, et al.
Publicado: (2020)

The Efficacy of Upfront Intracranial Radiation with TKI Compared to TKI Alone in the NSCLC Patients Harboring EGFR Mutation and Brain Metastases
por: Wang, Chunyu, et al.
Publicado: (2019)

PRO: Do We Still Need Whole-Brain Irradiation for Brain Metastases?
por: Popp, Ilinca, et al.
Publicado: (2023)

Detection of EGFR Mutations in Cerebrospinal Fluid of EGFR-Mutant Lung Adenocarcinoma With Brain Metastases
por: Shi, Liang, et al.
Publicado: (2021)

Comparison of whole brain radiation therapy for synchronous brain metastases with irradiation protecting the hippocampus versus whole brain radiotherapy for sequential brain metastases to boost irradiation in the treatment of brain metastases from SCLC: study protocol for a randomized controlled trial
por: Zhang, Xiaofang, et al.
Publicado: (2022)

Efficacy of dacomitinib in patients with EGFR‐mutated NSCLC and brain metastases
por: Zhang, Jinyao, et al.
Publicado: (2021)

Circulating Exosomal Integrin β3 Is Associated with Intracranial Failure and Survival in Lung Cancer Patients Receiving Cranial Irradiation for Brain Metastases: A Prospective Observational Study
por: Chen, Guann-Yiing, et al.
Publicado: (2021)

Brain metastases in patients with non-small cell lung cancer: the role of mutated-EGFRs with an exon 19 deletion or L858R point mutation in cancer cell dissemination
por: Hsiao, Shih-Hsin, et al.
Publicado: (2017)

Upfront whole brain radiotherapy for multiple brain metastases in patients with EGFR-mutant lung adenocarcinoma
por: Li, Changhui, et al.
Publicado: (2019)

Post-treatment intracranial hemorrhage of brain metastases from hepatocellular carcinoma
por: Kim, Kyung Su, et al.
Publicado: (2015)

CD44‐associated radioresistance of glioblastoma in irradiated brain areas with optimal tumor coverage
por: Liu, Wei‐Hsiu, et al.
Publicado: (2019)

Rationale for the Use of Upfront Whole Brain Irradiation in Patients with Brain Metastases from Breast Cancer
por: Tallet, Agnes V., et al.
Publicado: (2014)

Current status and recent advances in resection cavity irradiation of brain metastases
por: Minniti, Giuseppe, et al.
Publicado: (2021)

Re-Irradiation by Stereotactic Radiotherapy of Brain Metastases in the Case of Local Recurrence
por: Touati, Ruben, et al.
Publicado: (2023)

Nucleus Near-Infrared (nNIR) Irradiation of Single A549 Cells Induces DNA Damage and Activates EGFR Leading to Mitochondrial Fission
por: Gbetuwa, Momoh, et al.
Publicado: (2022)

Management of brain metastases with stereotactic radiosurgery alone versus whole brain irradiation alone versus both
por: El Gantery, Mahmoud M, et al.
Publicado: (2014)

Intracranial control after Cyberknife radiosurgery to the resection bed for large brain metastases
por: Vogel, Jennifer, et al.
Publicado: (2015)

Bevacizumab and risk of intracranial hemorrhage in patients with brain metastases: a meta-analysis
por: Yang, Lin, et al.
Publicado: (2017)

Intracranial Tumor Cell Migration and the Development of Multiple Brain Metastases in Malignant Melanoma()()
por: Simonsen, Trude G., et al.
Publicado: (2016)

Brain metastases in lung adenocarcinoma: impact of EGFR mutation status on incidence and survival
por: Stanic, Karmen, et al.
Publicado: (2014)

Radiomic Signatures for Predicting EGFR Mutation Status in Lung Cancer Brain Metastases
por: Zheng, Lie, et al.
Publicado: (2022)

The effectiveness of EGFR-TKIs against brain metastases in EGFR mutation-positive non-small-cell lung cancer
por: Bai, Hao, et al.
Publicado: (2017)

Recurrent spinal primitive neuroectodermal tumor with brain and bone metastases: A case report
por: Chen, Frank, et al.
Publicado: (2017)

Effect of Different Timing of Local Brain Radiotherapy on Survival of EGFR-Mutated NSCLC Patients with Limited Brain Metastases
por: Wang, Yu, et al.
Publicado: (2023)

Treatment outcomes of EGFR-TKI with or without locoregional brain therapy in advanced EGFR-mutant non-small cell lung cancer patients with brain metastases
por: Linh, Do Mai, et al.
Publicado: (2023)

Single isocenter stereotactic irradiation for multiple brain metastases: current situation and prospects
por: Uto, Megumi, et al.
Publicado: (2022)

The First Survival Score for Patients Aged ≥80 Years Irradiated for Brain Metastases
por: Rades, Dirk, et al.
Publicado: (2022)

Whole Brain Radiation Therapy Plus Stereotactic Radiosurgery in the Treatment of Brain Metastases Leading to Improved Survival in Patients With Favorable Prognostic Factors
por: Khan, Muhammad, et al.
Publicado: (2019)

Identification of Patients with Brain Metastases with Favorable Prognosis After Local and Distant Recurrence Following Stereotactic Radiosurgery
por: Jiang, Xuechao
Publicado: (2020)

Efficacy of EGFR‐TKIs with or without upfront brain radiotherapy for EGFR‐mutant NSCLC patients with central nervous system metastases
por: Saida, Yu, et al.
Publicado: (2019)

Intracranial Response Rate in Patients with Breast Cancer Brain Metastases after Systemic Therapy
por: Niwinska, Anna, et al.
Publicado: (2022)

Intracranial Efficacy of Systemic Therapy in Patients with Asymptomatic Brain Metastases from Lung Cancer
por: Sun, Min-Gwan, et al.
Publicado: (2023)

LDA-SVM-Based EGFR Mutation Model for NSCLC Brain Metastases: An Observational Study
por: Hu, Nan, et al.
Publicado: (2015)

Influence of afatinib dose on outcomes of advanced EGFR-mutant NSCLC patients with brain metastases
por: Tan, Wan-Ling, et al.
Publicado: (2018)

Radiotherapy in brain metastases from EGFR-mutated non-small cell lung cancer
por: Bhandari, Shruti, et al.
Publicado: (2021)

Brain Microstructural Changes Associated With Neurocognitive Outcome in Intracranial Germ Cell Tumor Survivors
por: Tso, Winnie Wan Yee, et al.
Publicado: (2021)

The role of brain radiotherapy for EGFR- and ALK-positive non-small-cell lung cancer with brain metastases: a review
por: Nardone, Valerio, et al.
Publicado: (2023)

The Prevention of Brain Metastases in Non-Small Cell Lung Cancer by Prophylactic Cranial Irradiation
por: Witlox, Willem J. A., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_bpgnntp64tnlj19l029625igvb